The pattern of incident fractures according to fracture site in people with T1D

Abstract

Higher incidences of fractures are seen in people with type 1 diabetes (T1D), but knowledge on different fracture sites is sparse. We found a higher incidence mainly for distal fracture sites in people with T1D compared to controls. It must be further studied which fractures attributed to the higher incidence rates (IRs) at specific sites. Introduction People with T1D have a higher incidence of fractures compared to the general population. However, sparse knowledge exists on the incidence rates of individual fracture sites. Therefore, we examined the incidence of various fracture sites in people with newly treated T1D compared to matched controls. Methods All people from the UK Clinical Practice Research Datalink GOLD , of all ages with a T1D diagnosis code (n = 6381), were included. People with T1D were matched by year of birth, sex, and practice to controls (n = 6381). Fracture IRs and incidence rate ratios (IRRs) were calculated. Analyses were stratified by fracture site and sex. ResultsThe IR of all fractures was significantly higher in people with T1D compared to controls (IRR: 1.39 (CI95%: 1.24-1.55)). Compared to controls, the IRR for people with T1D was higher for several fracture sites including carpal (IRR:

Fracture patterns in adult onset type 1 diabetes and associated risk factors – A nationwide cohort study

“…With this study, we identified risk at specific fracture sites in T1D compared with controls. The findings of a higher fracture risk of any fracture in people with T1D compared with controls corresponded well with other similar studies and recent meta-analyses [6,8,21,22]. We saw a higher risk of MOFs, which also were in accordance with previous epidemiological studies of T1D for theses fracture sites [23][24][25].…”

“…Furthermore, these risk factors may also differ depending on the type of fracture, as certain types, such as peripheral fractures, are primarily associated with falls [5,6]. Currently, risk factors for fractures in T1D have only been determined in a general sense or for specific fracture types, rather than for different fracture types within a single population [7,8]. Moreover, people with T1D face the necessity of insulin therapy, along with the added concerns of hyperor hypoglycemia incidents and the increased risk of late diabetic complications.…”

The Relationship Between Fracture and Mortality in a Chinese Maintenance Hemodialysis Patients Cohort

“…The types of fractures are different in different populations, in people with type 1 diabetes, the most common fracture sites are carpal, clavicle, foot, humerus and tibia/fibula. 7 In our study, the higher proportion of rib fractures and vertebral fractures may be related to the routine chest CT and abdominal X-ray examinations performed in hemodialysis patients. Since a large proportion of hemodialysis patients are elderly patients with mobility difficulties, they often need to be carried between wheelchairs and beds, which is often done by family members who lack professional facilities, which may increase the chance of rib fractures.…”