Arch Dermatol
 1960
DOI: 10.1001/archderm.1960.01580050121019
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The Pathologic Dynamics of Acne Vulgaris

John S. Strauss1
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Cited by 170 publications

(49 citation statements)
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“…It is our feeling that sebum provides the "fuel" for the development in a susceptible individual of the inflammatory lesions characteristic of the disease. 1 Our data indicates that the severest cases of acne occur in patients with large sebaceous glands and high sebum production. 2 Although there are undoubtedly other governing factors in the pathogenesis of the disease, the fact remains that suppression of the large postpubertal glands can favorably alter the course of the disease.…”
mentioning
confidence: 52%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It is our feeling that sebum provides the "fuel" for the development in a susceptible individual of the inflammatory lesions characteristic of the disease. 1 Our data indicates that the severest cases of acne occur in patients with large sebaceous glands and high sebum production. 2 Although there are undoubtedly other governing factors in the pathogenesis of the disease, the fact remains that suppression of the large postpubertal glands can favorably alter the course of the disease.…”
mentioning
confidence: 52%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The microcomedone is the initial lesion in acne and may be present in normal-appearing skin of acne patients, as has been demonstrated by biopsies [ 76 ]. Keratinocyte hyperproliferation of both comedones and microcomedones compared with normal follicles has been demonstrated immunohistochemically by the use of the antibody Ki-67.…”
Section: Follicular Hyperkeratinizationmentioning
confidence: 84%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Thus, in this case, P. acnes was most likely a pathogen. P. acnes may be significant in the pathogenesis of acne (42), and some patients with acne have associated bone disorders. Acne in a severe form (acne fulminans) may be associated with arthralgia (27), arthritis (8) and, less commonly, osteolytic lesions which do not generally contain bacteria (20,35,37).…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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