The Pathogenesis of Noncaseating Tuberculosis of the Skin and Lymph Glands

Mellon, Ralph R.

doi:10.1001/archderm.1937.01480030042004

Cited by 13 publications

(3 citation statements)

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“…Moscovic [27] contends that Hamazaki corpuscles may represent in vivo L forms of mycobacteria. These larger coccoid forms also resemble the 'yeast-like', 'fungoid', and 'sporoid' forms of mycobacteria observed in aged cultures from sarcoid le sions by Crawford [10], Mellon and Beinhauer [25] [33]. In this present case, these forms were clearly distinguishable from the similar sized but solid-staining, irregular, black anthracotic granules commonly observed in the lung (fig.…”

Section: Report Of a Casesupporting

confidence: 78%

“…This has been determined by the inoculation of myco bacterial L forms into animals with the ensuing production of sarcoid lesions by Xalabarder [47]; and also by the histopathologic findings of Schaumann and Hallberg [34], A phis [4], Vanek [40], Vanck and Schwarz [41], Richter and Bartak [29]; the bactériologie findings of Mellon and Fisher [24], Crawford [10], Mellon and Beinhauer [25], Beinhauer and Mellon [5]; and autopsy find ings of acid-fast bacteria in human beings with systemic sarcoidosis by Ronchese [30].…”

Section: Introductionmentioning

confidence: 99%

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Variably Acid-Fast Bacteria in a Case of Systemic Sarcoidosis and Hypodermitis Sclerodermiformis

Cantwell¹

1981

Dermatology

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The histologic finding of variably acid-fast coccoid forms in all the available biopsy material (skin, lymph nodes, and lung) from a case of coexisting scleroderma-like cutaneous disease (hypodermitis sclerodermiformis) and systemic sarcoidosis is reported The morphologic size, shape, and staining characteristics of these microbes, along with the presence in the lung of ‘large bodies’, suggest that these microbes are cell wall deficient L forms of mycobacteria. Culture of the skin of the scleroderma-like lesion yielded Staphylococcus epidermidis, and the relationship of this isolate to the histologic findings of bacteria is disussed, as well as the possible pathogenic role played by L forms of mycobacteria in collagen disease and systemic sarcoidosis.

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Section: Report Of a Casesupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Variably Acid-Fast Bacteria in a Case of Systemic Sarcoidosis and Hypodermitis Sclerodermiformis

Cantwell¹

1981

Dermatology

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“…On the basis of their dissociative relationship with the tubercle bacillus, our orientation of these organisms into the clinical and pathologic picture has already been presented. (Mellon and Beinhauer, 1937).…”

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confidence: 99%

The Polyphasic Potencies of the Bacterial Cell; Its General Biologic and Chemotherapeutic Significance

Mellon

1942

J Bacteriol

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The experimental data of this communication really represent the fourth paper in a series dealing with the effects of the sulfonamide drugs on certain pathogenic bacteria as inifluenced by variability. The first three papers have already appeared. Mellon, 1941) (Hadley and and (Hadley, Hadley, and Leathen, 1941). The pattern of bacterial variability associated with the action of these drugs in vivo has had no clear recognition heretofore; but, by way of anticipation, a clue to its nature is afforded by a certain similarity with what have sometimes been referred to as "environmental modifications."These latter have never-been considered as true bacterial variants, or even as playing any r6le in the variation process, for two rather specious reasons. The first of these concerns their lack of stability; and the second, the misconception that they were merely morphologic alterations and therefore of no importance.In the first paper of the series we demonstrated that the erroneously styled series of involution forms of the pneumococcus occurring in vivo under the impact of sulfanilamide action, were actually phasic entities. This fact was considered of transcendent importance too, because the gradient of disappearing virulence which the several phases represented, made them vulnerable to destruction by the immunologic forces of the host. The proof of our contention as to the essentially phasic nature of the pleomorphic cell-forms, was made possible by their isolation in culture where their biochemical and colonial differences became measurable.It is our belief that the pattern of variability shown in the pneumococcus, while in itself distinctive, is not in principle a specific effect of the action of the sulfonamide compounds. In fact, the variability phenomena of the organism we are now about to describe have not been evoked by the action of these drugs; and yet the principles involved do not seem to differ and even the phenomena themselves have much in common. On the other hand, the latter are so much more inclusive that a unique opportunity is provided for the integration and clarification of relationships that have long been in dispute. This is due in part to the fact that it is unusual to encounter a single organism possessing such a range of variability as this one did.Incidentally, the intimate bearing of such considerations on the mode of action of the drugs that have made a new epoch in the history of medicine, should make 1 on August 4, 2020 by guest

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Pathogenesis of Noncaseating Epithelioid Tuberculosis of Hypoderm and Lymph Glands

Beinhauer¹

1938

Arch Dermatol

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The Pathogenesis of Noncaseating Tuberculosis of the Skin and Lymph Glands

Cited by 13 publications

References 13 publications

Variably Acid-Fast Bacteria in a Case of Systemic Sarcoidosis and Hypodermitis Sclerodermiformis

Variably Acid-Fast Bacteria in a Case of Systemic Sarcoidosis and Hypodermitis Sclerodermiformis

The Polyphasic Potencies of the Bacterial Cell; Its General Biologic and Chemotherapeutic Significance

Pathogenesis of Noncaseating Epithelioid Tuberculosis of Hypoderm and Lymph Glands

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