The Pathogenesis of Cutaneous Myxedema

Asboe-Hansen, G

doi:10.1001/archderm.1960.01580010038005

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1961

1982

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Cited by 12 publications

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“…Serotonin (5-hydroxytryptamine) has been demonstrated in mast cell granules of certain animals, but not in man. According to Ratzenhofer and 36,37 proposed an essentially similar theory that mast cells secrete hyaluronic acid. Most investigators, however, disagree with this theory because of the distribution of mast cells and the inability to demonstrate the presence of hyaluronic acid in mast cells.38"42 These latter investigators showed that metachromasia of mast cell granules remained after hyaluronidase digestion both in vivo and in vitro.…”

Section: Microscopic Descriptionmentioning

confidence: 99%

Solitary Mastocytosis (Urticaria Pigmentosa)

Helwig¹

1961

Arch Dermatol

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Section: Microscopic Descriptionmentioning

confidence: 99%

Solitary Mastocytosis (Urticaria Pigmentosa)

Helwig¹

1961

Arch Dermatol

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Localized Myxedema Involving the Upper Extremities

Cohen¹,

Benua²,

Rawson³

1963

Arch Intern Med

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Prolonged persistence of a large pericardial effusion and hemodynamic evidence of cardiac tamponade during treatment of myxedema

Das

Lieberman

Schussler

1982

Clinical Cardiology

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Summary:We describe clinical, echocardiographic, and catheterization findings that were present initially and during therapy in a myxedematous patient with a large pericardial effusion and tamponade. Treatment with thyroxine resulted in a marked improvement of most of the clinical features of hypothyroidism and some improvement in cardiac function. However, the pericardial effusion as well as clinical and laboratory evidence of tamponade persisted for 2 months after full replacement doses of T4 had been achieved. The tamponade was finally relieved by fenestration of the parietal pericardium. These findings are consistent with evidence of an abnormality of pericardial drainage that persists for months after other thyroid hormone dependent functions are normalized by thyroxine replacement. Therefore prompt surgical drainage rather than dependence on medical therapy alone is indicated in myxedematous patients who have cardiac tamponade.

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The Pathogenesis of Cutaneous Myxedema

Cited by 12 publications

References 8 publications

Solitary Mastocytosis (Urticaria Pigmentosa)

Solitary Mastocytosis (Urticaria Pigmentosa)

Localized Myxedema Involving the Upper Extremities

Prolonged persistence of a large pericardial effusion and hemodynamic evidence of cardiac tamponade during treatment of myxedema

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