1997
DOI: 10.1001/archderm.133.8.1003
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The pathogenesis of chronic idiopathic urticaria

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Cited by 60 publications
(49 citation statements)
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“…However, in many patients, the mechanisms governing regional mast cell or basophil activation are still unknown. The possible relationship between urticarial reactions and HLA alleles involved in autoimmune responses should be explored [1,4,7,11]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, in many patients, the mechanisms governing regional mast cell or basophil activation are still unknown. The possible relationship between urticarial reactions and HLA alleles involved in autoimmune responses should be explored [1,4,7,11]. …”
Section: Discussionmentioning
confidence: 99%
“…However, present research emphasizes the role of mast cells as the primary effector cells in chronic urticaria and IgG histamine- releasing autoantibodies against high-affinity IgE receptors in about 30% of the patients. Less frequently, IgE-dependent urticaria has been confirmed [1]. …”
Section: Introductionmentioning
confidence: 99%
“…Although mast cell degranulation and histamine release are known to occur, the eliciting factors are not clear. Since most of the patients remain symptomatic despite antihistamines, it is supposed that other mediators, such as kinins, prostaglandins, and leukotrienes (LT) may also constitute the appearance of the symptoms seen in CU [19]. Intolerance to pseudoallergens has been suggested to be a cause of chronic urticaria [27,28].…”
Section: Introductionmentioning
confidence: 99%
“…One–half of the patients demonstrate whealing beyond 6 months but one–fifth of patients persist with considerable disability and reduction of quality of life beyond 10 years [1, 2]. Despite an exhaustive and expensive diagnostic approach, searches for etiologies of chronic urticaria have been mostly frustrating [3]. …”
Section: Introductionmentioning
confidence: 99%