The past, present, and future of breast cancer models for nanomedicine development

Boix-Montesinos, Paz; Soriano-Teruel, Paula M.; Armiñán, Ana; Orzáez, Mar; Vicent, Marı́a J.

doi:10.1016/j.addr.2021.03.018

Cited by 83 publications

(59 citation statements)

References 266 publications

(432 reference statements)

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“…At an intermediate stage, newly developed biomimetic devices may accurately model nanomedicines' behavior in vivo. Advances include bioprinting [176,177] and organ/tumor-on-a-chip models may support the accurate recapitulation of the interplay of nanomedicines with physiological barriers [178][179][180], while threedimensional spheroid/organoid cultures in microfluidic devices may reveal how interstitial flow affects cell binding and how particle size influences nanoparticle diffusion and accumulation [181][182][183]. In cancer research, the development of organotypic multicellular tumor spheroids aims to preserve and faithfully reproduce tumor structure by involving stromal and immune cell components.…”

Section: Pre-clinical Pharmacology and Toxicology Studiesmentioning

confidence: 99%

“…The lack of predictability regarding the benefit of a given nanomedicine to a patient may derive from dependence on PK efficacy, tissue distribution, target site accumulation, penetration, and drug release at the target site. These aspects impact in vivo performance and differ between animal models and patients, thereby underscoring a lack of disease models that faithfully recapitulate human disease [188][189][190]. The inconsistency of the enhanced permeability and retention effect (EPR) in primary tumors and metastases provides an important barrier to nanomedicine targeting and penetration [191].…”

Section: Pre-clinical Pharmacology and Toxicology Studiesmentioning

confidence: 99%

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Current hurdles to the translation of nanomedicines from bench to the clinic

Đorđević

Medel

Conejos‐Sánchez

et al. 2021

Drug Deliv. and Transl. Res.

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138

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The field of nanomedicine has significantly influenced research areas such as drug delivery, diagnostics, theranostics, and regenerative medicine; however, the further development of this field will face significant challenges at the regulatory level if related guidance remains unclear and unconsolidated. This review describes those features and pathways crucial to the clinical translation of nanomedicine and highlights considerations for early-stage product development. These include identifying those critical quality attributes of the drug product essential for activity and safety, appropriate analytical methods (physical, chemical, biological) for characterization, important process parameters, and adequate pre-clinical models. Additional concerns include the evaluation of batch-to-batch consistency and considerations regarding scaling up that will ensure a successful reproducible manufacturing process. Furthermore, we advise close collaboration with regulatory agencies from the early stages of development to assure an aligned position to accelerate the development of future nanomedicines. Graphical abstract

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Section: Pre-clinical Pharmacology and Toxicology Studiesmentioning

confidence: 99%

Section: Pre-clinical Pharmacology and Toxicology Studiesmentioning

confidence: 99%

Current hurdles to the translation of nanomedicines from bench to the clinic

Đorđević

Medel

Conejos‐Sánchez

et al. 2021

Drug Deliv. and Transl. Res.

Self Cite

138

View full text Add to dashboard Cite

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“…BALB/c female mice (7–8 weeks old) were purchased from the Vital River Laboratory Animal Technology Co. Ltd. (Beijing, China). According to previous reports, the 4T1 breast carcinoma lung metastasis model including the orthotopic models and intra tail-vein injections models were set up (Cheng et al., 2019 ; Boix-Montesinos et al., 2021 ; Jiang et al., 2021 ). In the orthotopic model experiments, when the primary tumor volume reached 100 mm 3 , mice with comparable tumor volume were selected and randomly separated into various groups for ensuing the treatments.…”

Section: Methodsmentioning

confidence: 99%

Black phosphorus conjugation of chemotherapeutic ginsenoside Rg3: enhancing targeted multimodal nanotheranostics against lung cancer metastasis

Xiong

Yuan

et al. 2021

Drug Delivery

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It is a significant challenge in lung cancer chemophotothermal (CPT) therapy to develop multifunctional theranostic nanoagent (MTN) for precise targeting and successful tumor treatments, especially for lung metastasis. To overcome this problem, we effectively design and construct multifunctional black phosphorus (BP) nanoagents, BPs/G-Rg3@PLGA. BPs quantum dots (BPsQDs) are co-loaded onto poly(lactic-co-glycolic acid) (PLGA) with subsequent conjugations of a cancer therapeutic compound, ginsenoside Rg3 (G-Rg3), in this composite nanoagent. The in vivo delivery findings suggest that BPs/G-Rg3@PLGA has an excellent affinity for primary tumors and metastatic lung tumors. Furthermore, when paired with near-light irradiation, BPs/G-Rg3@PLGA shows superior controllable CPT therapy synergetic therapeutics, significantly increasing photothermal tumor ablation effectiveness. Mechanistically, heating causes rapid G-Rg3 release from the non-complex, and thermal therapy induces apoptosis, culminating in the reduction of lung cancer metastasis. Additionally, in vivo and in vitro findings support the biocompatibility of BPs/G-Rg3@PLGA. This thesis identifies a versatile BPs-based MTN for lung cancer metastasis control.

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“…Breast cancer is a malignant tumor that occurs in the epithelial cells of the breast and is highly heterogeneous in time and space, and its extremely high incidence poses a serious threat to women’s physical and mental health and life safety ( Boix-Montesinos et al, 2021 ; Burstein et al, 2021 ). Zhang developed an assembling gold nanoparticles in triangular pyramid DNA (TP-Au nps) based on the principle of electrostatic attraction between negatively charged DNA tetrahedra and positively charged Au nps ( Zhang et al, 2019a ).…”

Section: Sers Technology For Exosome Detectionmentioning

confidence: 99%

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

Yang

Jia

2022

Front. Bioeng. Biotechnol.

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Exosomes are small nanoscale vesicles with a double-layered lipid membrane structure secreted by cells, and almost all types of cells can secrete exosomes. Exosomes carry a variety of biologically active contents such as nucleic acids and proteins, and play an important role not only in intercellular information exchange and signal transduction, but also in various pathophysiological processes in the human body. Surface-enhanced Raman Spectroscopy (SERS) uses light to interact with nanostructured materials such as gold and silver to produce a strong surface plasmon resonance effect, which can significantly enhance the Raman signal of molecules adsorbed on the surface of nanostructures to obtain a rich fingerprint of the sample itself or Raman probe molecules with ultra-sensitivity. The unique advantages of SERS, such as non-invasive and high sensitivity, good selectivity, fast analysis speed, and low water interference, make it a promising technology for life science and clinical testing applications. In this paper, we briefly introduce exosomes and the current main detection methods. We also describe the basic principles of SERS and the progress of the application of unlabeled and labeled SERS in exosome detection. This paper also summarizes the value of SERS-based exosome assays for early tumor diagnosis.

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The past, present, and future of breast cancer models for nanomedicine development

Abstract: Graphical abstract

Cited by 83 publications

References 266 publications

Current hurdles to the translation of nanomedicines from bench to the clinic

Current hurdles to the translation of nanomedicines from bench to the clinic

Black phosphorus conjugation of chemotherapeutic ginsenoside Rg3: enhancing targeted multimodal nanotheranostics against lung cancer metastasis

Advances in the Application of Exosomes Identification Using Surface-Enhanced Raman Spectroscopy for the Early Detection of Cancers

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