The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia

Sun, Ruirui; He, Zhaoxuan; Ma, Peihong; Yin, Shuai; Yin, Tao; Liu, Xiaoyan; Jin, Lu; Qu, Yuzhu; Zhang, Tingting; Huang, Liuyang; Suo, Xueling; Lei, Du; Gong, Qiyong; Liang, Fanrong; Zeng, Fang

doi:10.1007/s11682-019-00249-7

Cited by 25 publications

(47 citation statements)

References 74 publications

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“…It was consistent with our former study of interhemispheric functional connectivity in IBS (Qi et al, 2016b). The two enhanced betweenness centrality nodes were located in the anterior corona radiata and superior longitudinal fasciculus, which were near the frontal lobe and insula (Zeng et al, 2013;Liu et al, 2018;Sun et al, 2020). The positive correlation with PSQI represents that the frontal lobe and insula might be important in the modulation of sleep quality in FD patients.…”

Section: Discussionsupporting

confidence: 91%

“…Besides, the anterior corona radiata was the connecting fiber bundle within the frontal lobe, the superior longitudinal fasciculus was the connecting fiber bundle from frontal lobe to insula and ends in the posterior part of the brain, the posterior thalamic radiation was the ascending fiber bundle from thalamus to cerebral cortex, and the corpus callosum was the connecting fiber bundle to bridge two hemispheres. These results also fitted the functional alteration in GM-related studies, such as decreased functional connectivity of insula (Sun et al, 2020); decreased GM density in the middle frontal gyrus, right precentral gyrus, and insula (Zeng et al, 2013); and decreased connectivity between insula and thalamus (Liu et al, 2018). Our former study also found altered amplitude of low-frequency fluctuation in insula and thalamus (Qi et al, 2020).…”

Section: Discussionsupporting

confidence: 87%

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Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Weng

Liu

et al. 2021

Front. Hum. Neurosci.

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Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia (FD).Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two-sample t-test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and the clinical and neuropshychological information.Results: Patients with FD and healthy controls showed small-world properties in functional connectome of white matter. Compared with healthy controls, the FD group showed decreased global properties (Cp, S, Eglobal, and Elocal). Four pairs of fiber bundles that are connected to the frontal lobe, insula, and thalamus were affected in the FD group. Duration and Pittsburgh Sleep Quality Index positively correlated with the betweenness centrality of white matter regions of interest.Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula, and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Weng

Liu

et al. 2021

Front. Hum. Neurosci.

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“…The fMRI data preprocessing was carried out with SPM12 (SPM12, http://www.fil.ion.ucl.ac.uk/spm ) and DPARSF 4.5 ( 32 ) ( http://rfmri.org/DPARSF ). The main steps included the following: (1) discarding the first 10 timepoints; (2) slice-timing correction, realignment, and discarding subjects with a mean framewise displacement value exceeding 0.5 mm or a maximum displacement greater than one voxel size ( 33 , 34 ); (3) reorienting functional and T1 images with six rigid-body parameters; (4) coregistering T1 images to functional space, segmentation, and normalizing the functional images to Montreal Neurological Institute (MNI) space; (5) correcting head motion with Friston 24-parameter model ( 35 , 36 ), removing linear trend, and regressing out the white matter and cerebrospinal fluid signals; (6) re-sampling the functional images to 3-mm 3 cubic voxels and smoothing functional images with a 6-mm Gaussian kernel of full width at half maximum; (7) temporally filtering (0.01–0.08 Hz) ( 37 ) to generate the ALFF maps; (8) transforming the ALFF map to the zALFF map with normal z transformation.…”

Section: Methodsmentioning

confidence: 99%

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

et al. 2020

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“…Results from two studies (Li et al, 2015 ; Sun et al, 2020 ) on acupuncture for a pathological condition were inconsistent with previous research (Sun et al, 2013 ) on deqi , showing that the effect of deqi was related to the processing of somatosensory or pain signals. The discrepancy between results was explained by small sample sizes, different physiological states, diseases, and acupoints.…”

Section: Discussionmentioning

confidence: 72%

Progress of Acupuncture Therapy in Diseases Based on Magnetic Resonance Image Studies: A Literature Review

Zhang

et al. 2021

Front. Hum. Neurosci.

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The neural mechanisms of acupuncture are not well-understood. Over the past decades, an increasing number of studies have used MRI to investigate the response of the brain to acupuncture. The current review aims to provide an update on acupuncture therapy in disease. The PubMed, Embase, Web of Science, and Cochrane Library databases were searched from inception to January 31, 2021. Article selection and data extraction were conducted by two review authors. A total of 107 publications about MRI in acupuncture were included, the collective findings of which were as follows: (1) stroke and GB34 (Yanglingquan) are the most studied disease and acupoint. Related studies suggested that the mechanism of acupuncture treatment for stroke may associate with structural and functional plasticity, left and right hemispheres balance, and activation of brain areas related to movement and cognition. GB34 is mainly used in stroke and Parkinson's disease, which mainly activates brain response in the premotor cortex, the supplementary motor area, and the supramarginal gyrus; (2) resting-state functional MRI (rs-fMRI) and functional connectivity (FC) analysis are the most frequently used approaches; (3) estimates of efficacy and brain response to acupuncture depend on the type of sham acupuncture (SA) used for comparison. Brain processing after acupuncture differs between patients and health controls (HC) and occurs mainly in disorder-related areas. Factors that influence the effect of acupuncture include depth of needling, number and locations of acupoints, and deqi and expectation effect, each contributing to the brain response. While studies using MRI have increased understanding of the mechanism underlying the effects of acupuncture, there is scope for development in this field. Due to the small sample sizes, heterogeneous study designs, and analytical methods, the results were inconsistent. Further studies with larger sample sizes, careful experimental design, multimodal neuroimaging techniques, and standardized methods should be conducted to better explain the efficacy and specificity of acupuncture, and to prepare for accurate efficacy prediction in the future.

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The participation of basolateral amygdala in the efficacy of acupuncture with deqi treating for functional dyspepsia

Cited by 25 publications

References 74 publications

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia

The Spontaneous Activity Pattern of the Middle Occipital Gyrus Predicts the Clinical Efficacy of Acupuncture Treatment for Migraine Without Aura

Progress of Acupuncture Therapy in Diseases Based on Magnetic Resonance Image Studies: A Literature Review

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