volume 7, issue 10, P854-867 2015
DOI: 10.18632/aging.100831
View full text
|
|
Share
Sarah Waye, Aisha Naeem, Muhammad Umer Choudhry, Erika Parasido, Lucas Tricoli, Angiela Sivakumar, John P. Mikhaiel, Venkata Yenugonda, Olga C. Rodriguez, Sana D. Karam, Brian R. Rood, Maria Laura Avantaggiati, Chris Albanese

Abstract: Medulloblastoma (MB), a primitive neuroectodermal tumor, is the most common malignant childhood brain tumor and remains incurable in about a third of patients. Currently, survivors carry a significant burden of late treatment effects. The p53 tumor suppressor protein plays a crucial role in influencing cell survival in response to cellular stress and while the p53 pathway is considered a key determinant of anti-tumor responses in many tumors, its role in cell survival in MB is much less well defined. Herein, w…

expand abstract