2013
DOI: 10.4172/2167-0889.1000117
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The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver

Abstract: The p53 protein is a critical stress-response mediator and signal coordinator in cellular metabolism and environmental exposure to deleterious agents. In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide. Previous studies carried out using human populations, mouse models, and cell culture analyses have provided evidence that this amino ac… Show more

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Cited by 8 publications
(2 citation statements)
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References 70 publications
(138 reference statements)
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“…[6][7][8] In contrast to these examples, a common coding region SNP in p53 at codon 72 has failed to show compelling impact on cancer risk, despite the fact that this SNP is predicted to alter p53 structure, 9 and data from numerous groups that this SNP alters p53 function. [9][10][11][12][13][14][15] An intriguing yet poorly understood fact is that this SNP shows a linear association with latitude: specifically, the arginine 72 (R72) variant shows a linear increase in frequency in populations away from the equator, whereas the proline 72 variant (P72) is most common in populations near the equator. 16,17 To date genome-wide association studies have failed to find an association between the p53 codon 72 SNP and cancer.…”
Section: Introductionmentioning
confidence: 99%
“…[6][7][8] In contrast to these examples, a common coding region SNP in p53 at codon 72 has failed to show compelling impact on cancer risk, despite the fact that this SNP is predicted to alter p53 structure, 9 and data from numerous groups that this SNP alters p53 function. [9][10][11][12][13][14][15] An intriguing yet poorly understood fact is that this SNP shows a linear association with latitude: specifically, the arginine 72 (R72) variant shows a linear increase in frequency in populations away from the equator, whereas the proline 72 variant (P72) is most common in populations near the equator. 16,17 To date genome-wide association studies have failed to find an association between the p53 codon 72 SNP and cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Multiple single nucleotide polymorphisms (SNPs) have been identified in TP53 [27,28]; one of the most studied is the Arg72Pro variant. This genetic polymorphism has been associated with various cancers, inflammatory diseases, and stroke [29][30][31][32]. Also, the TP53 Arg72Pro genetic variant has been found to be involved in osteoporosis; the proline variant has been associated with an increased risk of suffering osteoporosis [15].…”
Section: Discussionmentioning
confidence: 99%