The origin of ovarian carcinomas: A developmental view

Auersperg, Nelly; Woo, Michelle; Gilks, C. Blake

doi:10.1016/j.ygyno.2008.05.031

Cited by 64 publications

(49 citation statements)

References 14 publications

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“…Historically, the origin of human EOC was presumed to be in the OSE, or in the epithelial lining of inclusion cysts that had arisen from the OSE (Bell & Scully 1994, Feeley & Wells 2001, Bell 2005, Auersperg et al 2008, Pothuri et al 2010. Recently, growing evidence has challenged this theory and identified the secretory cell of the distal fallopian tube as the putative EOC precursor (Dubeau 1999, Piek et al 2001, Carcangiu et al 2004, Lee et al 2007, Carlson et al 2008, Mehra et al 2011.…”

Section: Tissue Of Origin Of Hgseocmentioning

confidence: 99%

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Garson¹,

Vanderhyden²

2015

Reproduction

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The lack of significant progress in the treatment of epithelial ovarian cancer (EOC) underscores the need to gain a better understanding of the processes that lead to chemoresistance and recurrence. The cancer stem cell (CSC) hypothesis offers an attractive explanation of how a subpopulation of cells within a patient's tumour might remain refractory to treatment and subsequently form the basis of recurrent chemoresistant disease. This review examines the literature defining somatic stem cells of the ovary and fallopian tube, two tissues that give rise to EOC. In addition, considerable research has been reviewed, that has identified subpopulations of EOC cells, based on marker expression (CD133, CD44, CD117, CD24, epithelial cell adhesion molecule, LY6A, ALDH1 and side population (SP)), which are enriched for tumour initiating cells (TICs). While many studies identified either CD133 or CD44 as markers useful for enriching for TICs, there is little consensus. This suggests that EOC cells may have a phenotypic plasticity that may preclude the identification of universal markers defining a CSC. The assay that forms the basis of quantifying TICs is the xenograft assay. Considerable controversy surrounds the xenograft assay and it is essential that some of the potential limitations be examined in this review. Highlighting such limitations or weaknesses is required to properly evaluate data and broaden our interpretation of potential mechanisms that might be contributing to the pathogenesis of ovarian cancer.

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Section: Tissue Of Origin Of Hgseocmentioning

confidence: 99%

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Garson¹,

Vanderhyden²

2015

Reproduction

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“…This has led to the development of hypotheses linking ovulation to development of ovarian cancer. While the precise etiology of ovarian cancer is unknown, there is a strong correlation between an increased number of lifetime ovulations and increased risk of ovarian cancer (11). There are at least three distinct components of ovulation that likely contribute to this risk: proliferation of OSE following ovulation, proliferation in response to the gonadotropins, and release of inflammatory cytokines during ovulation.…”

Section: Ovarian Cancermentioning

confidence: 99%

“…The FTE lies in close proximity and is contiguous with the OSE, although the two types of epithelium have different molecular characteristics (11). Both types of cells express certain epithelial markers, such as cytokeratins, but the FTE expresses E-cadherin while the OSE does not, although E-cadherin is often expressed in inclusion cysts (26).…”

Section: The Fallopian Tube Epithelium and Hereditary Risk Of Ovarianmentioning

confidence: 99%

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

King

Burdette

2011

BMB Reports

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“…Secondary origin of ovarian cancer. Particularly based on anatomical/morphological observations is a model of secondary Müllerian origin of ovarian cancer cells [16,36]. This model assumed spreading of tumor cells from parts of mesonephric origin, i.e.…”

Section: Disputed Origin Of the Epithelial Ovarian Cancermentioning

confidence: 99%

Ovarian cancer: Origin and factors involved in carcinogenesis with potential use in diagnosis, treatment and prognosis of the disease

Záveský

Jancárková²,

Kohoutová³

2011

neo

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Ovarian cancer representing the most lethal gynecologic malignancy escapes from the efforts to manage the disease. We reviewed the current state of the research considering three main concepts on origin of ovarian cancer including epithelialmesenchymal transition, secondary origin from Müllerian system and cancer stem cell hypothesis. Cytogenetic and molecular characteristics of ovarian cancer are focused particularly on microRNA expression studies revealing huge potential in recent years, although other transcriptomic, proteomic, epigenetic, epidemiologic and immunological factors are touched upon, too. Routine and investigated diagnostic and treatment methods are outlined and several factors revealed to be associated with prognosis of the disease. Despite the huge progress on elucidating factors involved in ovarian cancer carcinogenesis, still remains urgent need to improve both the diagnostics as well as the treatment.

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The origin of ovarian carcinomas: A developmental view

Cited by 64 publications

References 14 publications

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

Ovarian cancer: Origin and factors involved in carcinogenesis with potential use in diagnosis, treatment and prognosis of the disease

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