The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

Seawright, A. A.; Nolan, Christopher C.; Shaw, G. R.; Chiswell, Robyn K.; Norris, Ross; Moore, Michael R.; Smith, Maree J.

doi:10.1002/(sici)1522-7278(199902)14:1<135::aid-tox17>3.0.co;2-l

Cited by 134 publications

(78 citation statements)

References 11 publications

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“…The oral toxicity is about 30 fold less than toxicity by i.p. [106]. CYN has two known derivatives, one of them is toxic, 7-epicylindrospermopsin [1] and the other virtually nontoxic, deoxy-cylindrospermosin [86].…”

Section: Cylindrospermopsinsmentioning

confidence: 89%

“…Acute poisoning induces death probably due to heart failure, as suggested by Seawright et al [106]. At toxic concentrations, lesion development is quite minor compared to the speed of clinical evolution.…”

Section: Cylindrospermopsinsmentioning

confidence: 99%

“…In the thymus, there is widespread necrosis of the cortical lymphocytes. The spleen is characterized by necrosis with phagocytosis of cellular fragments by macrophages [6,36,106]. Recently CYN has been found to display genotoxic activity [56,109].…”

Section: Cylindrospermopsinsmentioning

confidence: 99%

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Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems

Briand¹,

Jacquet²,

et al. 2003

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-Toxigenic cyanobacteria are photosynthetic prokaryotes that are most often recognized in marine and freshwater systems, such as lakes, ponds, rivers, and estuaries. When environmental conditions (such as light, nutrients, water column stability, etc.) are suitable for their growth, cyanobacteria may proliferate and form toxic blooms in the upper, sunlit layers. The biology and ecology of cyanobacteria have been extensively studied throughout the world during the last two decades, but we still know little about the factors and processes involved in regulating toxin production for many cyanobacterial species. In this minireview, we discuss these microorganisms, and more especially the toxins they produce, as a potential and important health risk for wild and domestic animals.

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Section: Cylindrospermopsinsmentioning

confidence: 89%

Section: Cylindrospermopsinsmentioning

confidence: 99%

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Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems

Briand¹,

Jacquet²,

et al. 2003

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“…Its main target organs are the liver and kidney [54,55], but its citotoxicity is common to other organs. Cylindrospermopsin has a late and progressive acute toxicity, associated to protein synthesis inhibition [56].…”

Section: Toxicological Profiles Of Cyanotoxinsmentioning

confidence: 99%

Emerging health issues of cyanobacterial blooms

Manganelli

Scardala

Stefanelli

et al. 2012

Annali Dell'Istituto Superiore Di Sanità

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Abstract. This paper describes emerging issue related to cyanobacterial dynamics and toxicity and human health risks. Data show an increasing cyanobacteria expansion and dominance in many environments. However there are still few information on the toxic species fitness, or on the effects of specific drivers on toxin production. Open research fields are related to new exposure scenario (cyanotoxins in water used for haemodialysis and in food supplements); to new patterns of co-exposure between cyanotoxins and algal toxins and/or anthropogenic chemicals; to dynamics affecting toxicity and production of different cyanotoxin variants under environmental stress; to the accumulation of cyanotoxins in the food web. In addition, many data gaps exist in the characterization of the toxicological profiles, especially about long term effects.

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“…First report by Terao et al (1994) described a massive necrosis of lymphocytes in the cortical layer of the thymus of male mice given a single intraperitoneal dose of 0.2 mg kg -1 purified CYN [24]. Atrophy in lymphoid tissue of the spleen (follicular lymphocyte loss due to lymphophagocytosis) and thymus (degeneration and necrosis of cortical lymphocytes) has also been observed in orally exposed (4.4-8.3 mg CYN kg -1 ) mice [25]. In other rodent experimental model induction of lymphophagocytosis in the mouse spleen at dosing with the cell-free extract at 0.05 mg CYN kg -1 was shown [26].…”

Section: Discussionmentioning

confidence: 99%

Experimental immunology First report of cylindrospermopsin effect on human peripheral blood lymphocytes proliferation in vitro

Poniedziałek¹,

Rzymski²,

Wiktorowicz³

2012

cejoi

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The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

Cited by 134 publications

References 11 publications

Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems

Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems

Emerging health issues of cyanobacterial blooms

Experimental immunology First report of cylindrospermopsin effect on human peripheral blood lymphocytes proliferation in vitro

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