The Oral Manifestations of Cyclic (Periodic) Neutropenia

Gorlin, Robert J.

doi:10.1001/archderm.1960.01580030038004

Cited by 23 publications

(5 citation statements)

References 16 publications

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“…As far as the oral manifestations are concerned, ulcerations. chronic gmgivitis and chronic periodontitis have been reported in relation to the different forms of neutropenia (Gorlin & Chaudry 1960, Wade & Stafford 1963, Cohen 1966, Degnan & Parlow 1973, Binon & Dykena 1974. This case report of chronic idiopathic neutropenia represents a follow-up presentation of a patient first documented by Baehni et al (1983).…”

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confidence: 71%

A case report of chronic neutropenia: clinical and ultrastructural findings

et al. 1992

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This case report of severe periodontitis concerns a young male patient with chrotiic idiopathic neutropenia seen between 1981 and 1983 by the School o'i Dental Medicine of Geneva and from 1984 to 1988 by the Eastman Dental Hospital of London. The patient was maintained by intermittent systemic antibiotics, subgingiva! chlorhexidine irrigatioti, conventional debridement, brushing, and wire-mesh and composite splmting of loose teeth. After leavmg school, at the patient's express wish, the extreme downhill pattern of the periodontitis resulted in removal of affected teeth and overdenture construction. The extracted teeth and associated soft tissues were examined for relevant plaque and host response features. The intact morphotypes associated with the advancing front of the lesion were invariably Gram-negative or positive coccoid cells, or less commonly short rods, as in all documented forms of periodotitis. Connective tissue destruction was associated with a leucocyte accumulation comprising mainly polymorphonuclear neutrophils (PMN) and plasma cells. Both were observed degenerated more deeply than in routine adult periodontitis, including PMN lysosome loss and lymphocyte maturation within peripheral blood vessels. Only in one instance, one part of the superficial connective tissue of one block contained bacteria. It was concluded that the features of plaque and the lesion suggest a typical first line of defence response as in other forms of periodontitis. From the consideration of the 10 years clinical history of the patient, it is clear that non-surgical management is possible even in extreme cases, without any compromise of the patient's oral or systemic health, and in accord with the patient's wishes.

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confidence: 71%

A case report of chronic neutropenia: clinical and ultrastructural findings

et al. 1992

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“…The same findings were reported by Wintrobe et al (180). Ulceration, chronic gingivitis and chronic periodontitis have been reported in relation to the different forms of neutropenia (23, 40, 47, 65, 176). Ulceration may be episodic in cyclic neutropenia but tends to be more persistent in chronic neutropenia (137).…”

Section: Neutropeniamentioning

confidence: 99%

Influences of systemic diseases on periodontitis in children and adolescents

Meyle¹,

Gonzáles²

2001

Periodontology 2000

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Systemic diseases affecting the host response as primary immunodeficiencies or secondary defects caused by lack of nutrients or changes in the local tissues are very often accompanied by early-onset prepubertal periodontitis. Local treatment in combination with systemic antibiotics may in milder forms improve the situation, but in many cases the success is questionable and premature loss of teeth occurs. Since the genetic basis of many of the diseases has been identified, future developments permit the correction of at least some of these defects by gene therapy.

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“…An equally rare condition with periodontal manifestations was cyclic neutropaenia. Reimann & de Beradinis (1949), Levine (1959) and Andrews et al (1965) published case reports, but Cohen & Morris (1961) and Gorlin & Chaudhry (1960) reviewed the condition. At this time, only thirty-six cases had been described and were characterized by periodic disappearance of neutrophils, with concomitant oral ulceration.…”

Section: Further Search For An Underlying Systemic Statementioning

confidence: 99%

Juvenile periodontitis: an historical review

1982

J of Oral Rehabilitation

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A review of the literature on juvenile periodontitis has been undertaken. This paper traces the historical development of the appreciation of the condition. Some of the numerous early attempts to define a systemic background are noted, and the concept of 'periodontosis' and its subsequent influence, e.g. on epidemiological and clinical studies are discussed. The refining over the last 20 years of the concept of aggressive periodontal disease in the young is recorded. The patterns of bone loss in juvenile periodontitis and some forms of treatment are presented, together with evidence on its histopathology. Recent research has tended to concentrate on the microbiology and immunological background of juvenile periodontitis and a number of these studies are discussed.

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The Oral Manifestations of Cyclic (Periodic) Neutropenia

Cited by 23 publications

References 16 publications

A case report of chronic neutropenia: clinical and ultrastructural findings

A case report of chronic neutropenia: clinical and ultrastructural findings

Influences of systemic diseases on periodontitis in children and adolescents

Juvenile periodontitis: an historical review

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