The Optic Nerve Head in Glaucomatous Optic Neuropathy

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy

“…The results suggest that Glia-KO mice have topological damage of RGCs. In the ONH, Glia-KO mice exhibited loss of axonal markers at the posterior part of the glial lamina, consistent with previous reports of animal glaucoma models ( 36 , 37 ) and patients ( 28 ). Such similarities in tissue damage suggest that Glia-KO mice exhibit phenotypes potentially relevant to glaucoma.…”

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy

“…The results suggest that Glia-KO mice have topological damage of RGCs. In the ONH, Glia-KO mice exhibited loss of axonal markers at the posterior part of the glial lamina, consistent with previous reports of animal glaucoma models ( 36 , 37 ) and patients ( 28 ). Such similarities in tissue damage suggest that Glia-KO mice exhibit phenotypes potentially relevant to glaucoma.…”

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

“…Taken together these data from monkey, rat and mouse eyes are compatible with the notion of a direct axonal insult by a variety of mechanisms coupled with astrocyte withdrawal of trophic support due to “preoccupation” with or “distraction” by a profoundly altered biomechanical environment (Hernandez, 2000; Hernandez and Pena, 1997; Jamara et al, 2000). …”

Transforming growth factor‐β‐regulated gene transcription and protein expression in human GFAP‐negative lamina cribrosa cells

“…ECM genes upregulated in response to TGF-b1 in our study, which have been characterized in ONH in POAG, included collagen IV, collagen I, elastin and TIMP1 (Hernandez and Pena, 1997;Yuan and Neufeld, 2001). We also found that TGF-b1 upregulated its own expression, clearly demonstrating that TGF-b1 auto-induction occurs in LC cells, a capability which human lung fibroblasts also possess (Kelley et al, 1993).…”

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy

“…The results suggest that Glia-KO mice have topological damage of RGCs. In the ONH, Glia-KO mice exhibited loss of axonal markers at the posterior part of the glial lamina, consistent with previous reports of animal glaucoma models ( 36 , 37 ) and patients ( 28 ). Such similarities in tissue damage suggest that Glia-KO mice exhibit phenotypes potentially relevant to glaucoma.…”

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

“…Taken together these data from monkey, rat and mouse eyes are compatible with the notion of a direct axonal insult by a variety of mechanisms coupled with astrocyte withdrawal of trophic support due to “preoccupation” with or “distraction” by a profoundly altered biomechanical environment (Hernandez, 2000; Hernandez and Pena, 1997; Jamara et al, 2000). …”

Transforming growth factor‐β‐regulated gene transcription and protein expression in human GFAP‐negative lamina cribrosa cells

“…ECM genes upregulated in response to TGF-b1 in our study, which have been characterized in ONH in POAG, included collagen IV, collagen I, elastin and TIMP1 (Hernandez and Pena, 1997;Yuan and Neufeld, 2001). We also found that TGF-b1 upregulated its own expression, clearly demonstrating that TGF-b1 auto-induction occurs in LC cells, a capability which human lung fibroblasts also possess (Kelley et al, 1993).…”

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy

“…The results suggest that Glia-KO mice have topological damage of RGCs. In the ONH, Glia-KO mice exhibited loss of axonal markers at the posterior part of the glial lamina, consistent with previous reports of animal glaucoma models ( 36 , 37 ) and patients ( 28 ). Such similarities in tissue damage suggest that Glia-KO mice exhibit phenotypes potentially relevant to glaucoma.…”

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

“…Taken together these data from monkey, rat and mouse eyes are compatible with the notion of a direct axonal insult by a variety of mechanisms coupled with astrocyte withdrawal of trophic support due to “preoccupation” with or “distraction” by a profoundly altered biomechanical environment (Hernandez, 2000; Hernandez and Pena, 1997; Jamara et al, 2000). …”

Transforming growth factor‐β‐regulated gene transcription and protein expression in human GFAP‐negative lamina cribrosa cells

“…ECM genes upregulated in response to TGF-b1 in our study, which have been characterized in ONH in POAG, included collagen IV, collagen I, elastin and TIMP1 (Hernandez and Pena, 1997;Yuan and Neufeld, 2001). We also found that TGF-b1 upregulated its own expression, clearly demonstrating that TGF-b1 auto-induction occurs in LC cells, a capability which human lung fibroblasts also possess (Kelley et al, 1993).…”