The “ocular glymphatic clearance system”: a key missing piece of the Alzheimer’s disease-glaucoma puzzle found?

Wostyn, Peter

doi:10.1038/s41433-020-1008-8

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…Based on several lines of evidence the experimental description of a retinal glymphatic system had been anticipated for a number of years [18; 63] [64] [65] [66]. There was a need to explain the physiological variation of individual retinal layers [67] [68] [20]; the dynamic nature of another novel OCT finding, microcystic macular oedema (MMO) [58] [69] [70] [71]; the potential for local accumulation of neurotoxic products driving compartmentalised neurodegeneration [72]. Now that it is possible to design quantitative longitudinal studies with composite imaging modalities including OCT and MRI neuroprotective treatment strategies can be tested not only with regard to the principal action, but more importantly probably, with regard to their timing.…”

Section: Oct Helps To Interpret Mri Signal Changesmentioning

confidence: 99%

Interpretation of composite OCT/MRI findings: a clinical review of retinotopy

Bijvank,

Wenniger,

Graaf

et al. 2024

Preprint

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Optical coherence tomography (OCT) offers clinicians detailed in vivo structural imaging of individual retinal layers. This has lead to novel observations which were impossible by direct ophthalmoscopy. The technique also helps to re-introduce the concept of retinotopy to clinical practise. This review illustrates the anatomical foundation for retinotopy through detailed sketches of the pre- and post-laminar axons forming the optic nerve and their post-synaptic path from the dorsal lateral geniculate nucleus to the primary visual cortex in humans. With the mapped neuroanatomy in mind we use OCT-MRI pairs to discuss the patterns of neurodegeneration in eye and brain that are a consequence of the hard wired retinotopy: antero- and retrograde axonal degeneration which can, within the visual system, propagate trans-synaptically. The technical advances of OCT and MRI for the first time enable us to trace the signals of axonal degeneration through the visual system entirely at spectacular resolution. In addition to atrophic processes, we also summarize novel insights on tissue thickening mainly at the level of the optic disc, in particular peripaphillary hyperreflecitive ovoid mass like structures (PHOMS). In conclusion, the neuroanatomical insights provided by the combination of OCT and MRI allows us to separate incidental findings from sinister pathology and gives us new opportunities to tailor and monitor novel neuroprotective strategies.

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Section: Oct Helps To Interpret Mri Signal Changesmentioning

confidence: 99%

Interpretation of composite OCT/MRI findings: a clinical review of retinotopy

Bijvank,

Wenniger,

Graaf

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…The observation of the dynamic nature of PHOMS, which can develop de novo, increase or diminish in size [65; 66] coincides in time with the discovery of a retinal glymphatic system [22]. Based on several lines of evidence the experimental description of a retinal glymphatic system had been anticipated for a number of years [21; 68] [23]; the dynamic nature of MMO in the majority of cases [63] [74] [75] [76]; the potential for local accumulation of neurotoxic products driving compartmentalised neurodegeneration [77]. Now that it is possible to design quantitative longitudinal studies with composite imaging modalities including OCT and MRI neuroprotective treatment strategies can be tested not only with regard to the principal action, but more importantly probably, with regard to their timing.…”

Section: Helps To Interpret Mri Signal Changesmentioning

confidence: 99%

Clinical review of retinotopy

et al. 2021

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Two observations made 29 years apart are the cornerstones of this review on the contributions of Dr Gordon T. Plant to understanding pathology affecting the optic nerve. The first observation laid the anatomical basis in 1990 for the interpretation of optical coherence tomography (OCT) findings in 2009. Retinal OCT offers clinicians detailed in vivo structural imaging of individual retinal layers. This has led to novel observations which were impossible to make using ophthalmoscopy. The technique also helps to re-introduce the anatomically grounded concept of retinotopy to clinical practise. This review employs illustrations of the anatomical basis for retinotopy through detailed translational histological studies and multimodal brain-eye imaging studies. The paths of the prelaminar and postlaminar axons forming the optic nerve and their postsynaptic path from the dorsal lateral geniculate nucleus to the primary visual cortex in humans are described. With the mapped neuroanatomy in mind we use OCT-MRI pairings to discuss the patterns of neurodegeneration in eye and brain that are a consequence of the hard wired retinotopy: anterograde and retrograde axonal degeneration which can, within the visual system, propagate trans-synaptically. The technical advances of OCT and MRI for the first time enable us to trace axonal degeneration through the entire visual system at spectacular resolution. In conclusion, the neuroanatomical insights provided by the combination of OCT and MRI allows us to separate incidental findings from sinister pathology and provides new opportunities to tailor and monitor novel neuroprotective strategies.

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“…Interestingly, impaired CSF dynamics within the optic nerve SAS have been demonstrated in normaltension glaucoma (NTG) [5]. Given that there exists a perivascular transport system within the optic nerve, similar and likely continuous with the glymphatic system in the rest of the CNS, it is conceivable that some cases of NTG are actually the expression of glymphatic dysfunction in natural brain aging and CNS diseases, including Alzheimer's disease [6]. High-tension glaucoma, on the other hand, might then primarily result from pathological changes in ocular glymphatic solute transport, as reported by Nedergaard and colleagues.…”

Section: To the Editormentioning

confidence: 99%

The “ocular glymphatic clearance system”: a key missing piece of the Alzheimer’s disease-glaucoma puzzle found?

Cited by 6 publications

References 5 publications

Interpretation of composite OCT/MRI findings: a clinical review of retinotopy

Interpretation of composite OCT/MRI findings: a clinical review of retinotopy

Clinical review of retinotopy

Do normal-tension and high-tension glaucoma result from brain and ocular glymphatic system disturbances, respectively?

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