The occurrence of sensory neurons below the ganglion nodosum of the vagus

Brown, Margaret E.

doi:10.1002/cne.900630303

Cited by 10 publications

(4 citation statements)

References 1 publication

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“…Neuronal perikarya are a common but not regular feature of GLB (Hansen, 1981;Kummer and Addicks, 1982;McDonald and Blewett, 1981;Prechtl and Powley, 1985). Intravagal ganglion cells are particularly numerous near the branching of the recurrent laryngeal nerve (Brown, 1936;Stewart, 1920). Interestingly, this accumulation coincides with a high number of SLB which are rather infrequent at other locations (Kummer, 1985).…”

Section: General Structurementioning

confidence: 99%

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Vagal paraganglia of the rat

Kummer

Neuhuber

1989

J. Elec. Microsc. Tech.

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Paraganglia are associated with every branch of the rat vagus nerve except the pharyngeal branch. Some of the paraganglia closely resemble the glomus caroticum, whereas others appear like small, intensely fluorescent (SIF) cells of autonomic ganglia. The paraganglionic cells of SIF cell-like bodies (SLB) store catecholamines (the most abundant is probably noradrenaline) and in some cases neurotensin. The innervation pattern of SLB is variable and their physiological role remains unclear. Paraganglionic cells of glomus-like bodies (GLB) predominantly store dopamine and probably also to a lesser extent noradrenaline. These putative chemoreceptor organs receive sensory innervation from nodose ganglion neurons as revealed by degeneration experiments and by anterograde neuronal tracing. Substance P- and calcitonin gene-related peptide-immunoreactive fibres seen in the region of vascular entry into the GLB may account for some of these sensory fibres, but the peptide/classical transmitter stored in sensory terminals synapsing on paraganglionic cells is unknown. Ultrastructural immunocytochemistry revealed vasoactive intestinal polypeptide (VIP)-immunoreactive fibres lying in the interstitial space between paraganglionic cells and large capillaries. These fibres may originate from VIP-immunoreactive neurons, being frequently attached to GLB. The major difference between GLB and the glomus caroticum concerns their blood supply and related innervation: Arteries and arterioles do not penetrate into GLB and, accordingly, noradrenaline- and neuropeptide Y-containing nerve fibres are lacking within GLB. This peculiar arrangement of paraganglionic parenchyma and arterial blood supply may be one of the reasons for the different physiological properties of vagal and carotid arterial chemoreceptors.

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Section: General Structurementioning

confidence: 99%

“…Interestingly, this accumulation coincides with a high number of SLB which are rather infrequent at other locations (Kummer, 1985). Intravagal ganglion cells have been interpreted either as sensory or autonomic efferent neurons (Brown, 1936;Stewart, 1920). Ultrastructural observations suggest that both kinds occur.…”

Section: General Structurementioning

confidence: 99%

Vagal paraganglia of the rat

Kummer

Neuhuber

1989

J. Elec. Microsc. Tech.

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“…This explanation is attractive, since it might explain the presence of the cell bodies found within the vagus nerve (Brown, 1936;Foley, 1945;Hoffman & Kuntz, 1957). According to this hypothesis, the cell body for these fibres is not in the nodose ganglion, but has migrated down, say, the aortic nerve, making a large 'loop' as in Fig.…”

Section: Discussionmentioning

confidence: 99%

Direct nervous pathways between the cervical vagus and the aortic or superior laryngeal nerves traversed by baroreceptor, ‘pulmonary stretch’, and other fibres in the cat

Jewett¹

1964

The Journal of Physiology

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Only brief reports have appeared concerning carotid sinus baroreceptor fibres which conduct orthodromic impulses peripherally in the aortic nerve (Holmes, 1954;Bianconi & Raschi, 1959) and a vagal cardiac branch (Green, 1959) of the cat. The finding of a similar fibre in the cervical vagus of a dog (Jewett, 1964) led to the study to be described here. In the cat, besides these fibres, other baroreceptor fibres and some 'pulmonary stretch' fibres were found to conduct impulses peripherally in the aortic nerve. Electrical stimulation gave results which might be explained by assuming that these 'sensory' fibres do not pass to the central nervous system. METHODSNineteen cats weighing between 1-6 and 5-5 kg were anaesthetized with intra-peritoneal pentobarbitone sodium, 30-40 mg/kg body wt. With the cat supine the trachea was cannulated low in the neck. To facilitate dissection the block of tissue containing the pretracheal musculature, trachea, oesophagus, larynx, and lower pharynx was removed after nerves and vessels along the sides had been sectioned. To record respiration through changes in intra-thoracic oesophageal pressure, the oesophageal stump was cannulated with a polyethylene catheter inserted far enough to lie within the thorax. An unheated (28-33°C) liquid paraffin pool (sp.gr. 0.850) was formed within supported skin flaps; beneath its surface the vagus could be dissected readily to above the nodose ganglion. The nodose ganglion as well as the aortic nerve was identified by dissecting centrally along the superior laryngeal nerve. All recordings were made from the central segmentst (either at the cut end or along the nerve) of cut whole nerves from which the connective tissue had been removed with fine jeweller's forceps. Recording electrodes were AgCl-coated Ag wire of 0-025 in. diameter and stimulating electrodes were the same or of Pt; electrodes were positioned by Prior manipulators. Each of two square-wave stimulators could be made to fire at any given point on a freerunning oscilloscope sweep; the repetition frequency was usually either 50/sec or 100/sec. Recording electrode potentials were differentially amplified by a battery-powered Tektronix 122 pre-amplifier leading to a Tektronix 502 dual-beam oscilloscope. The high-frequency filters attenuated to half value at 1 kc and low-frequency filter attenuated to more than * Present address: Department of Physiology, University of California Medical Center, San Francisco, California 94122, U.S.A. t The term 'segment' is used to avoid the confusion arising from the usual terminology: a cut nerve has four ends, but only two segments.

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“…Heinbecker & O'Leary (145) described motor effects in the lungs and duodenum on stimu lation of fibers arising in the nod ose ganglion but they failed to find any effect on the heart (306). The presence of sensory neurons in th e vagus below the nodose down as far as the thorax has been reported (59).…”

Section: Annual Review Of Physiologymentioning

confidence: 96%

The Autonomic Nervous System

Hinsey¹

1939

Annu. Rev. Physiol.

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The occurrence of sensory neurons below the ganglion nodosum of the vagus

Cited by 10 publications

References 1 publication

Vagal paraganglia of the rat

Vagal paraganglia of the rat

Direct nervous pathways between the cervical vagus and the aortic or superior laryngeal nerves traversed by baroreceptor, ‘pulmonary stretch’, and other fibres in the cat

The Autonomic Nervous System

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