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Cited by 131 publications
(109 citation statements)
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References 41 publications
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“…This conclusion is supported by recent studies reporting that MTH1 expression levels increase with oxidative stress caused by ionizing radiation and hydrogen peroxide (34,35). This phenomenon may be related to the observed increase in MTH1 concentration by as much as 10-fold in a variety of cancerous tissues compared with surrounding normal tissues (3, 36-39).…”
Section: ␤-Estradiol (E2) Modulates 8-oxodg Incorporation and Oxidasupporting
confidence: 77%
“…This conclusion is supported by recent studies reporting that MTH1 expression levels increase with oxidative stress caused by ionizing radiation and hydrogen peroxide (34,35). This phenomenon may be related to the observed increase in MTH1 concentration by as much as 10-fold in a variety of cancerous tissues compared with surrounding normal tissues (3, 36-39).…”
Section: ␤-Estradiol (E2) Modulates 8-oxodg Incorporation and Oxidasupporting
confidence: 77%
“…Unlike chromatin-bound DNA, the nucleotide pool is relatively unprotected against cellular oxidants (Haghdoost et al, 2006), which are generated in the mitochondria or the cytoplasm. Furthermore, guanine deoxynucleotides and deoxynucleosides in particular can readily associate with labile intracellular iron (Gackowski et al, 2002;reviewed in Kruszewski, 2003), thus rendering them especially vulnerable to the Fenton reaction-generated hydroxyl radical.…”
Section: Resultsmentioning
confidence: 99%
“…It has been suggested that further processing, perhaps by 5 ¶(3 ¶)-nucleotidases, may give rise to 8-oxodG, which is not charged and can be removed from the cell, ultimately appearing in the urine (68). Recent data from the group of Harms-Ringdahl strongly imply that NUDT1 activity and, thus, the nucleotide pool represent a major source of extracellular 8-oxodG (98). These studies in cell culture used small interfering RNA gene expression knockdown methodology directed at human NUDT1.…”
Section: Sources Of Extracellular Oxidatively Modified Dna Lesionsmentioning
confidence: 99%