The nucleotide and partial amino acid sequences of rat fetuin

Rauth, Günther; Pöschke, Oliver; Fink, Edwin; Eulitz, Manfred; Tippmer, Stefanie; Kellerer, Monika; Häring, Hans-Ulrich; Nawratil, Peter; Haasemann, M; Jahnen‐Dechent, Willi; Müller‐Esterl, Werner

doi:10.1111/j.1432-1033.1992.tb16663.x

Cited by 130 publications

(95 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As yet, the fetuin family encompasses a series of tightly related proteins that are synthesized mostly in the liver and have been variably designated fetuin in sheep, pig and cow, α2-HS-glycoprotein (AHSG) in human, phosphoprotein of 63 kDa (pp63) in rat, or countertrypin in mouse and gerbil [2][3][4][5][6][7]. In fact, their close sequence similarities indicate that fetuin, AHSG, pp63 and countertrypin all originate from a single ancestral gene and are counterparts of a single protein, i.e.…”

Section: Introductionmentioning

confidence: 99%

Fetuin-B, a second member of the fetuin family in mammals

Olivier

Soury

Ruminy

et al. 2000

Biochemical Journal

112

View full text Add to dashboard Cite

A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner in the recovery phase of an acute inflammatory response. We now describe a second protein of the fetuin family, called fetuin-B, which is found at least in human and rodents. On grounds of domain homology, overall conservation of cysteine residues and chromosomal assignments of the corresponding genes in these species, fetuin-B is unambiguously a paralogue of fetuin-A. Yet, fetuin-A and fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. Differences and similarities in terms of gene regulation were also observed. Indeed, studies performed during development in rat and mouse showed for the first time high expression of a member of the fetuin family in adulthood, as shown with the fetuin-B mRNA in rat. However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat.

show abstract

Section: Introductionmentioning

confidence: 99%

Fetuin-B, a second member of the fetuin family in mammals

Olivier

Soury

Ruminy

et al. 2000

Biochemical Journal

112

View full text Add to dashboard Cite

show abstract

“…Fetuin A (α2-HS-glycoprotein) is a glycoprotein that acts as a natural inhibitor of the insulin-receptor tyrosine kinase in the liver and skeletal muscles [18][19][20][21]. The circulating levels of fetuin A show negative correlation to the insulin sensitivity [22,23].…”

Section: Introductionmentioning

confidence: 99%

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

2013

View full text Add to dashboard Cite

show abstract

“…Fetuin A is a protein secreted by hepatocytes that inhibits insulin receptor tyrosine kinase of adipose and muscle cells (1,2). Recently, its inhibitory potency on calcium phosphate precipitation has been linked to cardio-vascular (CV) calcification and has predicted CV and non-CV mortality in dialysis patients (3).…”

Section: Introductionmentioning

confidence: 99%

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. Methods: One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations. Results: Data from 63 women and 46 men aged 60G13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P!0.05). In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2-and 4.4-fold higher incidence of truncal obesity (PZ0.038) and hyper-triglyceridemia (PZ0.015) independent of nutritional status and inflammation. Conclusion: Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.

show abstract

The nucleotide and partial amino acid sequences of rat fetuin

Cited by 130 publications

References 44 publications

Fetuin-B, a second member of the fetuin family in mammals

Fetuin-B, a second member of the fetuin family in mammals

MCP-1 and fetuin A levels in patients with PCOS and/or obesity before and after metformin treatment

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Contact Info

Product

Resources

About