volume 66, issue 9, P5277-5283 1992
DOI: 10.1128/jvi.66.9.5277-5283.1992
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S D Senanayake, M A Hofmann, J L Maki, D A Brian

Abstract: For animal RNA viruses that replicate through an RNA intermediate, reported examples of bicistronic mRNAs with overlapping open reading frames in which one cistron is contained entirely within another have been made only for those with negative-strand or double-stranded genomes. In this report, we demonstrate for the positive-strand bovine coronavirus that an overlapping open reading frame potentially encoding a 23-kDa protein (names the I [for internal open reading frame] protein) and lying entirely within th…

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