Biochemical Pharmacology volume 78, issue 7, P889-897 2009 DOI: 10.1016/j.bcp.2009.07.010 View full text
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Andrew M. Smith, Gurpreet K. Dhawan, Zhenfa Zhang, Kiran B. Siripurapu, Peter A. Crooks, Linda P. Dwoskin

Abstract: Smoking is a significant health concern and strongly correlated with clinical depression. Depression is associated with decreased extracellular NE concentrations in brain. Smokers may be self-medicating and alleviating their depression through nicotine stimulated norepinephrine (NE) release. Several antidepressants inhibit NE transporter (NET) function, thereby augmenting extracellular NE concentrations. Antidepressants, such as bupropion, also inhibit nicotinic receptor (nAChR) function. The current study de…

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