2010
DOI: 10.1038/onc.2010.439
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Abstract: The microenvironment of the mammary gland has been shown to exert a deterministic control over cells from different normal organs during murine mammary gland regeneration in transplantation studies. When mouse mammary tumor virus (MMTV)-neu-induced tumor cells were mixed with normal mammary epithelial cells (MECs) in a dilution series and inoculated into epithelium- free mammary fat pads, they were redirected to noncarcinogenic cell fates by interaction with untransformed MECs during regenerative growth. In th… Show more

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Cited by 73 publications
(90 citation statements)
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References 33 publications
(39 reference statements)
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“…Evidence for this comes from studies showing that screen-detected invasive breast cancers may sometimes regress naturally without treatment [352]. This message is supported by a body of literature over the last four decades which has now been confirmed and strengthened via utilization of tools that permit researchers to unequivocally identify normal cells that once were cancer cells [292]. We suggest that cancer prevention, if not cures, are now foreseeable.…”
Section: Eiws and Diseasementioning
confidence: 79%
See 1 more Smart Citation
“…Evidence for this comes from studies showing that screen-detected invasive breast cancers may sometimes regress naturally without treatment [352]. This message is supported by a body of literature over the last four decades which has now been confirmed and strengthened via utilization of tools that permit researchers to unequivocally identify normal cells that once were cancer cells [292]. We suggest that cancer prevention, if not cures, are now foreseeable.…”
Section: Eiws and Diseasementioning
confidence: 79%
“…Within the last decade, a series of elegant experiments were conducted to address whether the target of carcinogens resides in the epithelial tissue or in the stroma (connective tissue) of the mammary gland [290][291][292]. It was observed experimentally that the tissue recombination of stroma exposed to a carcinogen with normal unexposed epithelial cells resulted in neoplasms, whereas the reverse combination did not, suggesting that the stroma, rather than individual cells in the epithelium, was the target of the carcinogen [290].…”
Section: Breast Cancermentioning
confidence: 99%
“…Exogenous cell types can compete to be incorporated into mammary niches during gland regeneration in vivo, resulting in the adoption of a mammary cell progenitor cell fate by the exogenous cell types (Boulanger et al, 2007;Booth et al, 2008;Bussard et al, 2010;Boulanger et al, 2012;Boulanger et al, 2013). By co-inoculating non-mammary or tumorigenic cell types with normal mammary epithelial cells (MECs), we have demonstrated that testicular cells (Boulanger et al, 2007), neuronal stem cells (Booth et al, 2008), Lin -bone marrow cells , embryonic stem cells (Boulanger et al, 2013), as well as human (Bussard et al, 2010) and mouse (Booth et al, 2011) cancer cells can all be reprogrammed in the developing mammary gland microenvironment. In addition, a wild-type mammary microenvironment can restore the function of mammary epithelial lobule progenitors from Wap-Int3 transgenic glands, which do not develop secretory alveoli during pregnancy .…”
Section: Introductionmentioning
confidence: 99%
“…Using the mouse model of HER2 breast cancer, mouse mammary tumor virus (MMTV)-driven ErbB2 (homolog of human HER2/ neu), 53 PI-MECs were shown to be cellular targets of HER2-mediated oncogenesis. [54][55][56] Indeed, ErbB2 tumorigenesis in mice increases with parity, and targeted removal of PI-MECs in vivo reduced tumor incidence in ErbB2 mice. [55][56][57] Likewise, clinical studies demonstrate that women during or right after pregnancy (when the number of PI-MECs is highest) have increased susceptibility for HER2 breast cancer.…”
mentioning
confidence: 99%