The Nonrandom Distribution of Facial Hemangiomas

Waner, Milton; North, Paula E.; Scherer, Kathrin; Frieden, Ilona J.; Waner, Alexandra; Mihm, Martín C.

doi:10.1001/archderm.139.7.869

Cited by 262 publications

(196 citation statements)

References 11 publications

(9 reference statements)

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“…Three of these five segmental hemangiomas which ulcerated were noted to have either focal areas of ulceration or crusting suggestive of impending ulceration immediately preceding laser treatment. In the absence of laser treatment, diffuse hemangiomas in a segmental distribution have been reported to be three times more likely to ulcerate than focal hemangiomas [30]. Although PDL has documented benefit in the setting of ulcerated hemangiomas, perhaps PDL carries an increased risk of inducing ulceration in diffuse or segmental hemangiomas in the proliferative phase, especially in those with evidence of impending ulceration.…”

Section: Discussionmentioning

confidence: 99%

Complications following pulsed dye laser treatment of superficial hemangiomas

et al. 2006

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Background and ObjectivePulsed dye laser (PDL) has been reported to be safe and effective in the management of superficial hemangiomas of infancy. We report 12 patients with hemangiomas with complications following PDL.Study Design/Materials and MethodsRecords of patients with hemangiomas and a known adverse outcome following PDL were reviewed.ResultsAll were treated early (age range: 5 days to 4 months), and all hemangiomas were facial with a superficial component. Eleven were treated with a 585 nm wavelength, fluence range of 4.7–7 J/cm2, without dynamic cooling. One patient received 7–12 J/cm2 utilizing a 595 nm wavelength with dynamic cooling. In eight cases, treatment led to severe ulceration with subsequent pain, scarring, and in one instance, life‐threatening hemorrhage. In four, permanent atrophic scarring was noted without ulceration.ConclusionsPDL treatment of superficial hemangiomas may rarely lead to significant complications including atrophic scarring and severe ulceration. Lasers Surg. Med. 38:116–123, 2006. © 2006 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Complications following pulsed dye laser treatment of superficial hemangiomas

et al. 2006

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“…Hemangiomas are present at birth in 30%-40% of cases, with the remainder generally being appreciated in the first months of life. More than one-half are located in the head and neck, with the most common sites of involvement being the midcheek, upper lip, and upper eyelid (22). Hemangiomas can be classified as focal, localized to a particular region, or diffuse and segmental.…”

Section: Benign Tumorsmentioning

confidence: 99%

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

et al. 2004

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“…[1][2][3] The lesions have unique growth characteristics, typically being absent or barely noticeable at birth, followed by a period of rapid growth and subsequent involution. The proliferating phase is characterized by abundant immature endothelial cells and adjacent pericyte-like cells ( Figure 1A), whereas the involuting phase is characterized by fewer and larger capillary-like vessels surrounded by connective tissue ( Figure 1B).…”

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Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

Calicchio

Collins

Kozakewich

2009

The American Journal of Pathology

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Infantile hemangiomas are characterized by rapid capillary growth during the first year of life followed by involution during early childhood. The natural history of these lesions creates a unique opportunity to study the changes in gene expression that occur in the vessels of these tumors as they proliferate and regress. Here we use laser capture microdissection and genome-wide transcriptional profiling of vessels from proliferating and involuting hemangiomas to identify differentially expressed genes. Relative to normal placental vessels, proliferating hemangiomas were characterized by increased expression of genes involved in endothelial-pericyte interactions, such as angiopoietin-2 (ANGPT2), jagged-1 (JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3). Insulin-like growth factor binding protein-3 (IGFBP3) was down-regulated in proliferating hemangiomas. Involuting hemangiomas were characterized by the expression of chronic inflammatory mediators, such as the chemokine, stromal cellderived factor-1 (SDF-1), and factors that may attenuate the angiogenic response, such as a member of the Down syndrome critical region (DSCR) family. The identification of genes differentially expressed in proliferating and involuting hemangiomas in vivo will contribute to our understanding of this vascular lesion, which remains a leading cause of morbidity in newborn children.

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The Nonrandom Distribution of Facial Hemangiomas

Cited by 262 publications

References 11 publications

Complications following pulsed dye laser treatment of superficial hemangiomas

Complications following pulsed dye laser treatment of superficial hemangiomas

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

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