The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis

Abstract

Our results unveil a novel inhibitory role for DLK1 in the regulation of angiogenesis, mediated by antagonism of the NOTCH pathway, and establish the basis for investigating its action in pathological settings.

Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration

“…Notably, we also observed a lower expression in Dlk1-null limb buds of genes associated with mesenchyme, whereas a tendency for higher amounts of some vascular transcripts was seen (Fig. 1F), which is in agreement with the known involvement of Dlk1 in bone and vascular morphogenesis Chen et al, 2011;Rodríguez et al, 2012).…”

The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta

“…Most interestingly, Pref-1 stimulated expression of proinflammatory cytokines including tumor necrosis factor a, monocyte chemoattractant protein-1, and interleukin-6 in human monocytes and mature adipocyte cell lines in vitro [11]. In addition, it has recently been demonstrated convincingly by Rodríguez and co-workers that Pref-1 has potent antiangiogenic properties besides its antiadipogenic effects [12].…”

MicroRNA-126 in Atherosclerosis

“…Dlk1 was shown to impair angiogenesis by inhibiting endothelial cell proliferation in a Notch-dependent manner. 8 Notch signaling is well known as crucial mediator of endothelial cell function during angiogenesis. 9 Although others report that Notch signaling is proinflammatory, 10 Schober and colleagues 6 clearly demonstrate that Notch1 signaling in endothelial cells promotes proliferation through Hes5 (Hairy and enhancer of split 5) induction.…”