The nitroxide Tempo inhibits hydroxyl radical production from the Fenton-like reaction of iron(II)-citrate with hydrogen peroxide

Shi, Fengqiang; Zhang, Peifeng; Mao, Yujia; Wang, Can; Zheng, Meiqing; Zhao, Zhongwei

doi:10.1016/j.bbrc.2016.12.174

Cited by 27 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of our in vitro study, it is possible that XJB‐5‐131 may reduce the oxidative damage to mitochondrial DNA by oxidizing the iron(II) species and hence blocking the Fenton‐like reaction (see Reaction ). This assumption, however, does not rule out the possibility that XJB‐5‐131 may also scavenge hydroxyl radicals by spin‐trapping pathway, as long as XJB‐5‐131 can appear at the right place and time, and with a high enough reactivity and concentration.…”

Section: Strategies To Combat Admentioning

confidence: 99%

“…Recently, we studied the effect of nitroxide Tempo on the physiologically important Fenton‐like reaction of iron(II)‐citrate with hydrogen peroxide. We demonstrated that Tempo can effectively inhibit the production of hydroxyl radical by oxidizing the iron(II)‐citrate to iron(III)‐citrate and hence blocking the Fenton‐like reaction (see Reaction ) …”

Section: Strategies To Combat Admentioning

confidence: 99%

See 1 more Smart Citation

Iron and oxidizing species in oxidative stress and Alzheimer's disease

Zhao

2019

Aging Medicine

Self Cite

View full text Add to dashboard Cite

This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractIron species can participate in the Fenton or Fenton-like reaction to generate oxidizing species that can cause oxidative damages to biomolecules and induce oxidative stress in the body. Furthermore, iron accumulation and oxidative stress have been shown to associate with the pathological progression of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). In this review, the role of iron species in generating the most deleterious free radical species (ie, hydroxyl radical) and effects of this species in causing oxidative stress in vivo are described. The implications of oxidative stress and the recently recognized cell death pathway (ie, ferroptosis) to AD are addressed. Strategies to combat this neurodegenerative disease, such as iron chelation and antioxidant therapies, and future research directions on this aspect are also discussed. K E Y W O R D SAlzheimer's disease, Fenton/Fenton-like reaction, hydroxyl radical, iron species, oxidative stress | 83 ZHAO treat neurodegenerative diseases. In this review, we examine the role of iron species in generating the most oxidatively deleterious ROS (ie, • OH) and describe the oxidative damages caused by this free radical and its consequence of inducing oxidative stress. We also discuss the association of oxidative stress with AD and the potential therapeutic strategy for this disease.

show abstract

Section: Strategies To Combat Admentioning

confidence: 99%

Section: Strategies To Combat Admentioning

confidence: 99%

Iron and oxidizing species in oxidative stress and Alzheimer's disease

Zhao

2019

Aging Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…This uncertainty is especially pronounced when comparing compounds with similar rate constants. For example, in the relevant documents, the ·OH‐scavenging abilities of GSH, Tempo, and DMSO are 8.6 × 10 9 L/mol/s, 4.5 × 10 9 L/mol/s, and 6.4 × 10 9 L/mol/s, respectively. (Table ) Therefore, if their ·OH‐scavenging abilities were judged according to the documents, the order of ·OH‐scavenging ability should be GSH > DMSO > Tempo.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and activity of a coumarin‐based fluorescent probe for hydroxyl radical detection

Zhang

Zhou

et al. 2019

Luminescence

View full text Add to dashboard Cite

As a type of reactive oxygen species (ROS), hydroxyl radical (·OH) is closely associated with many kinds of diseases. The present study aimed to develo p a novel OH fluorescent probe based on coumarin, a new compound that has not been previously reported. This probe exhibited good linear range and selectivity for ·OHl, and is able to avoid interference from some metal ions and other kinds of ROS (H2O2, O2.‐, 1O2, and HClO). Meanwhile, this probe has been used to evaluate the ·OH‐scavenging efficiency of different compounds, such as isopropyl alcohol, cytosine, uracil, Tempo, Glutathione (GSH), and dimethyl sulfoxide (DMSO). Therefore, the present study shows that this probe not only can effectively measure the level of ·OH, but also can assess the ·OH‐scavenging efficiency of different compounds. Furthermore this current study suggested that following further optimization, this probe may be potentially applied in the diagnosis of oxidative stress in human body.

show abstract

“…In addition, famotidine has been suggested to enhance the antioxidant defence mechanism against prooxidants; for example, Kesiova, Alexandrova, Yordanova, Kirkova, and Todorov () suggested that famotidine is able to enhance the activity of superoxide dismutase enzyme, which is an antioxidant enzyme catalyses the detoxification of superoxide ion (

O_{2}^{\cdot -}

) into molecules of lower toxicity such as hydrogen peroxide (H 2 O 2 ) and molecular oxygen (Hani & Bayachou, ; Shi et al, ). In semen, superoxide dismutase was found to be present in human semen, and its activity is crucial for sperm function (Rossi, Mazzilli, Delfino, & Dondero, ).…”

Section: Discussionmentioning

confidence: 99%

Famotidine does not affect human sperm fertility characteristics (motility, viability and DNA integrity) in vitro

Banihani

2019

Andrologia

View full text Add to dashboard Cite

Famotidine, a histamine-2 receptor antagonist, is commonly used to relieve the acidrelated gastrointestinal diseases; however, its effect on human sperm parameters, and hence on sperm function, is still undetermined. Here, we intended to measure human sperm motility, viability, and DNA integrity of ejaculated human sperm in the presence of famotidine at 0, 0.1, 1 and 10 mM concentrations in vitro. Forty-nine semen samples of normal count, motility, and morphology were included in this study. Sperm motility was assessed using Makler counting chamber and a phase contrast optics (200× magnification), whereas sperm viability was assessed using eosin-nigrosin staining procedure. The effect of famotidine on sperm DNA integrity was measured using flow cytometry. Famotidine at 0.1, 1 or 10 mM had insignificant effect on human sperm motility (progressive, p = .9594; and total, p = .8420), sperm viability (p = .6471), and content of DNA breaks in sperm (p > .05) compared with the control. In conclusion, famotidine at 0.1, 1 or 10 mM did not alter human sperm motility, viability or DNA integrity in vitro. Although, these findings indicate safety of famotidine in human sperm, further in vivo studies are required to establish the drug's safety. K E Y W O R D SDNA integrity, famotidine, human sperm, motility, viability

show abstract

The nitroxide Tempo inhibits hydroxyl radical production from the Fenton-like reaction of iron(II)-citrate with hydrogen peroxide

Cited by 27 publications

References 30 publications

Iron and oxidizing species in oxidative stress and Alzheimer's disease

Iron and oxidizing species in oxidative stress and Alzheimer's disease

Synthesis and activity of a coumarin‐based fluorescent probe for hydroxyl radical detection

Famotidine does not affect human sperm fertility characteristics (motility, viability and DNA integrity) in vitro

Contact Info

Product

Resources

About