Biochemical Pharmacology volume 77, issue 7, P1291-1301 2009 DOI: 10.1016/j.bcp.2008.12.010 View full text
Alfeu Zanotto-Filho, Daniel P. Gelain, Rafael Schröder, Luís F. Souza, Matheus A.B. Pasquali, Fábio Klamt, José Cláudio F. Moreira

Abstract: Nuclear factor kappa B (NFkappaB) has emerged as a crucial regulator of cell survival, playing important functions in cellular resistance to oxidants and chemotherapeutic agents. Recent studies showed that NFkappaB mediates cell survival through suppression of the accumulation of reactive species (RS) and a control of sustained activation of the Jun-N-terminal kinase (JNK) cascade. This work was undertaken in order to evaluate the role of NFkappaB in modulating the pro-oxidant effects of supplementation with v…

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