The New Herpesviruses

Drago, Francesco; Rebora, Alfredo

doi:10.1001/archderm.135.1.71

Cited by 31 publications

(9 citation statements)

References 106 publications

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“…2 We previously demonstrated that the co-infection with HHV-8 of HIV-1 positive patients can reduce not only B lymphocytes and CD4 T cells, but also CD8T cells. 3 Now we have studied the levels of some cytokines in the sera of 44 HIV-1 positive subjects, co-infected (24 individuals) or not co-infected with HHV-8 (20 individuals), in order to evaluate the role of HIV-1 infection and of HHV-8 co-infection in their production.…”

Section: Introduction Hhv-8 Is a New Herpesvirus Discovered In 1994mentioning

confidence: 96%

Cytokine detection in HIV‐1/HHV‐8 co‐infected subjects

Pugliese

Torre

Saini

et al. 2002

Cell Biochemistry & Function

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In a previous work we have evaluated some immunologic and haematologic parameters of HIV-1 positive subjects co-infected with HHV-8. A worsening of these values were generally described in these patients as compared with those HIV-1 positive, but negative for HHV-8. Now we have studied the influence of HHV-8 co-infection of HIV-1 positive subjects on the production of some cytokines to make clear the question of its role in the immuno-deregulation of the above-mentioned subjects. In particular we have analysed serum levels of IL-4 and IL-10, Th2 type T cells cytokines, IFN-gamma, an indirect marker of Th1 cells activation and IL-18, a cytokine produced by monocytic-macrophagic cells, which is able to induce IFN-gamma production and Th1 T lymphocytes activation. No significant differences were found as regards the IFN-gamma serum levels (92.1 +/- 24.3 pg ml(-1) in the case of HIV-1 positive/HHV-8 negative subjects and 96.0 +/- 17.4 pg ml(-1) in those HIV-1 positive/HHV-8 positive). In healthy subjects the mean level of this cytokine was 17.6 +/- 5.2 pg ml(-1) (significant difference with both the former values at p < 0.001). Moreover IL-4 and IL-10, which were undetectable in healthy individuals, showed the following values in HIV-1 positive/HHV-8 negative subjects: 31.9 +/- 2.7 pg ml(-1) and 119.8 +/- 85.1 pg ml(-1) respectively and in HIV-1 positive/HHV-8 positive subjects: 30.4 +/- 4.8 pg ml(-1) and 69.4 +/- 65.3 pg ml(-1) (not significant differences). In contrast IL-18 reached a mean level of 1001.2 +/- 360.5 pg ml(-1) in HIV-1 positive/HHV-8 negative subjects, but showed a significant reduction in HIV-1 positive/HHV-8 positive subjects (737.6 +/- 284.3 pg ml(-1) --> p < 0.05) and presented very low levels in healthy individuals (21.3 +/- 30.3 pg ml(-1)). Moreover a significant correlation (-0.984 --> p < 0.001) was noticed between IL-18 reduction in HIV-1 positive subjects co-infected with HHV-8 and the degree of positivity of HHV-8. These data suggest that HHV-8 co-infection has no influence on the switch Th1 --> Th2 in HIV-1 positive subjects, but is able to reduce IL-18 production, useful for Th1 subset restoration.

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Section: Introduction Hhv-8 Is a New Herpesvirus Discovered In 1994mentioning

confidence: 96%

Cytokine detection in HIV‐1/HHV‐8 co‐infected subjects

Pugliese

Torre

Saini

et al. 2002

Cell Biochemistry & Function

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“…Human herpesvirus 7 (HHV‐7) is a T‐lymphotropic virus and a member of the beta‐human herpesvirus subfamily. It can cause a primary infection by the age of 3 years, persists lifelong as a latent infection with shedding of the infectious virus in saliva, and it may reactivate if conditions of altered immunity develop 7–11 . So far the portal entry of HHV‐7, the site of primary infection, the mechanism of latency, and its etiologic role in any disease have not yet been fully determined.…”

Section: Introductionmentioning

confidence: 99%

Detection of human herpesvirus 7 in pityriasis rosea by nested PCR

et al. 2002

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“…Recently, research has focused on HHV-6 and HHV-7. In most cases, after primary infection in early childhood, these viruses establish a latent infection in a specific set of cells of their host and are capable of reactivation in conditions of altered immunity [11]. They are widely encountered in the general adult population (80–90%).…”

Section: Discussionmentioning

confidence: 99%

An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

et al. 2014

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Pityriasis rosea is a common erythematosquamous eruption, typically presenting along the cleavage lines of the skin. A wide spectrum of atypical manifestations may challenge even the most experienced physician. Here we report a rare case of a suberythrodermic pityriasis rosea with gigantic plaques after an influenza vaccination, and we discuss the possible triggers of atypical manifestations of such a common dermatological disease in the setting of an altered immunity.

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The New Herpesviruses

Cited by 31 publications

References 106 publications

Cytokine detection in HIV‐1/HHV‐8 co‐infected subjects

Cytokine detection in HIV‐1/HHV‐8 co‐infected subjects

Detection of human herpesvirus 7 in pityriasis rosea by nested PCR

An Atypical Case of Pityriasis Rosea Gigantea after Influenza Vaccination

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