The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage

The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model

“…MDA, a sensitive indicator of lipid peroxidation, increases following SAH. 8,24,25 These studies have also shown that dexmedetomidine, an alpha-2 agonist with possible antioxidant qualities, decreases MDA concentration following SAH and cerebral ischaemia and provides neuroprotective effects. In our study, we observed no difference in the MDA concentration of the control and SAH groups.…”

The biochemical, histopathological and clinical comparison of the neuroprotective effects of subcutaneous adalimumab and intravenous methylprednisolone in an experimental compressive spinal cord trauma model

“…The factors that play a role in this progressive process have not been fully elucidated. In addition to excessive release of glutamate and aspartate, intracellular calcium accumulation, activation of the arachidonic acid cascade, activation of various proteases such as caspase phospholipase-endonuclease, and induction of the peroxidation of lipids of free radical origin (30, 41,78), sympathetic stimulation also contributes to secondary injury mechanisms through altered blood flow and changes in microvascular permeability although the mechanism is not fully understood (4,14). Rapid neutrophil migration occurs to the injured region (9).…”

“…It is used successfully at a dose of 40 mg/kg subcutaneously every 2 weeks in the treatment of disorders such as Crohn's disease, ulcerative colitis, psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (13,14,42,43,59,65).…”

Dexmedetomidine Controls Agitation and Facilitates Reliable, Serial Neurological Examinations in a Non-Intubated Patient with Traumatic Brain Injury

“…While there are no reports specifically addressing the use of dexmedetomidine in traumatic brain injury, there appears to be consensus in the literature that dexmedetomidine causes no change or only slight decreases in intracranial pressure [20][21][22][23]. Furthermore, experimental studies have demonstrated a role for dexmedetomidine as a neuroprotective agent [24,25]. A single study in healthy human volunteers by Drummond et al [26] has reported that cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO 2 ) are preserved during dexmedetomidine administration.…”