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Cited by 2 publications
(1 citation statement)
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“…Indeed, in AD mouse models and human patients there is strong association between the deregulation of NGF signaling and the appearance of major disease hallmarks. The NGF-TrkA receptor complex of the basal forebrain cholinergic neurons (BFCN), which is a population of neurons heavily affected early in the progression of AD, has been shown to be disturbed in multiple ways [72][73][74][75]. During the progress of AD, decreased NGF processing results in an increase in pro-NGF compared to mature NGF concomitantly with the loss of the TrkA receptor, which in turn shifts the balance towards increased pro-NGF/p75 NTR pro-apoptotic signaling [8,76].…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in AD mouse models and human patients there is strong association between the deregulation of NGF signaling and the appearance of major disease hallmarks. The NGF-TrkA receptor complex of the basal forebrain cholinergic neurons (BFCN), which is a population of neurons heavily affected early in the progression of AD, has been shown to be disturbed in multiple ways [72][73][74][75]. During the progress of AD, decreased NGF processing results in an increase in pro-NGF compared to mature NGF concomitantly with the loss of the TrkA receptor, which in turn shifts the balance towards increased pro-NGF/p75 NTR pro-apoptotic signaling [8,76].…”
Section: Discussionmentioning
confidence: 99%