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Cited by 37 publications
(48 citation statements)
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References 70 publications
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“…With MRS, we determined the GABA levels before and after training in primary sensorimotor cortex and occipital cortex, because our previous work showed considerable brain activity in both visual and motor processing regions, in agreement with the unique visuomotor signature of this tracking task [ 7 ]. We found that (1) the behavioral data confirmed the typical contextual interference effects, i.e., random as compared to blocked practice led to temporary inferior performance levels during the acquisition phase but superior skill retention in both age groups, (2) the MRS data demonstrated a training-induced decrease in occipital GABA level during random practice but an increased GABA level during blocked practice and this effect was even more pronounced in older adults [ 6 ]. These findings are critical for a better understanding of neuroplasticity in older adults.…”
mentioning
confidence: 75%
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“…With MRS, we determined the GABA levels before and after training in primary sensorimotor cortex and occipital cortex, because our previous work showed considerable brain activity in both visual and motor processing regions, in agreement with the unique visuomotor signature of this tracking task [ 7 ]. We found that (1) the behavioral data confirmed the typical contextual interference effects, i.e., random as compared to blocked practice led to temporary inferior performance levels during the acquisition phase but superior skill retention in both age groups, (2) the MRS data demonstrated a training-induced decrease in occipital GABA level during random practice but an increased GABA level during blocked practice and this effect was even more pronounced in older adults [ 6 ]. These findings are critical for a better understanding of neuroplasticity in older adults.…”
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confidence: 75%
“…Using magnetic resonance spectroscopy (MRS), we explored the neurochemical basis of the CI effect via determination of the practice-induced modulation of gamma-aminobutyric acid (GABA), i.e. the chief inhibitory neurotransmitter that also plays a major role in brain plasticity [ 6 ]. Young and older participants were trained on 3 variations of a bimanual visuomotor tracking task over 3 days, according to either a blocked or random practice schedule.…”
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confidence: 99%
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“…Another neural factor that may be important is age-related reductions in the brain's major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). GABA levels measured using magnetic resonance spectroscopy (MRS) have been found to be reduced in older adults compared to younger adults in the occipital cortex (12)(13)(14), in frontal and parietal regions (13,15), and in supplementary motor area and sensorimotor cortex (12,13,16). Furthermore, individual differences in GABA in specific cortical regions have been associated with individual differences in some aspects of cognitive performance (13,14,17).…”
Section: Introductionmentioning
confidence: 99%