The nephroprotective effects of taurine in acute kidney injury due to rhabdomyolysis

The study of the prooxidant-antioxidant equilibrium in the kidney tissue and blood on the background of ceruloplasmin administration under the conditions of acute kidney injury

“…As a result of the AKI modeling, a deep disruption of the prooxidant-antioxidant balance, that occurs in the animals' organism, has been detected, which corresponds to the literature [1,8,14].…”

“…The animals were divided into three groups. The first group consisted of the intact animals, the second one: the animals with AKI, that was caused on the background of intramuscular administration of 50% glycerol solution at a dose of 8mg/kg [14]. The third group included the animals, which in 30 minutes after modeling of AKI was injected ceruloplasmin (Biopharma, Ukraine) at a dose of 7 mg/kg intraperitoneally.…”

“…The state of prooxidant-antioxidant balance was estimated by the content of the malonic dialdehyde (MDA) and oxidatively modified proteins (OMP) in blood and kidney tissue, activity of the catalase and glutathione peroxidase in blood plasma and kidney tissue using standard biochemical methods [14].…”

“…One of the promising areas of AKI treatment are the antioxidants that inhibit free radical processes and prevent the destruction of cell membranes within the pathological processes. The pathogenesis of AKI is related with the peroxidation of lipids [8,11,12,14], leading to imbalance among prooxidants and antioxidants, hence to the development of oxidative stress.…”

Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney

“…In AKI, HOCl-mediated tissue injury has been demonstrated by specific biomarkers, such as the chlorinated product of tyrosine, 3-chlorotyrosine (Cl-Tyr) [ 120 ]. Taurine supplementation (an important HOCl scavenger) exerts an excellent renoprotective effect in AKI induced by ischemia, doxorubicin, and rhabdomyolysis [ [121] , [122] , [123] ].…”