The neonatal Fc receptor (FcRn) expression in the human skin

The effect of the neonatal Fc receptor on human IgG biodistribution in mice

“…Based on our current results, and the observed various tissue distribution pattern changes in FcRn KO mice, we believe it is more likely that FcRn also play roles in transporting antibody into, or out of, specific organs. This is consistent with the reported widespread expression of FcRn in tissues, including the liver, 18 bone marrow, 19,20 lungs, 21 kidneys, 10,22 skin, 23,24 and spleen. 25 For example, the T/B ratios of IgG1 in the liver and spleen were higher in FcRn KO mice across all time points.…”

Nonclassical major histocompatibility complex I–like Fc neonatal receptor (FcRn) expression in neonatal human tissues

“…However, our previous studies, performed both in mice and in humans, have demonstrated that human endothelial FcRn expression is not as ubiquitous as initially thought [13,15,16].…”

“…Meanwhile, the presence of FcRn was revealed by several groups that focused on various human tissues and types of cells, both neonatal and adult: syncytiotrophoblast [6], intestinal epithelial cells [7], monocytes, macrophages, dendritic cells [8], renal glomerular and tubular epithelial cells [9], placental endothelial cells [10], bronchial epithelial cells [11], neutrophils [12], mammary gland ductal and acinar epithelial cells [13], keratinocytes [14,15], melanocytes, and hair follicle and sebaceous glands [15]. However, our previous studies, performed both in mice and in humans, have demonstrated that human endothelial FcRn expression is not as ubiquitous as initially thought [13,15,16].…”

Neonatal Fc receptor and IgG-based therapeutics

“…FcRn has been detected in the hair follicle, sebaceous gland, epidermal keratinocyte and melanocytes. 44 However, the exact role in each cell type is still unknown.…”