The Necessity of Dietary Vitamin B6 to Selenium Biopotency for Tissue Selenium and Glutathione Peroxidase in Rats.

Protective effect of vitamin B6 in chromium-induced oxidative stress in liver

“…The complete abolition of Cr-induced oxidative stress by pre-treatment with B6 could be due its ability to increase vitamins C and E (non significant), GSH (non significant) and GPX (Tables 1 and 2) along with its free radical scavenging potential by acting as a substrate for oxyradicals (Kannan and Jain, 2004;Bilski et al, 2000). While the reasons for the higher levels of vitamins C and E are not known, vitamin B6 increases GPX activity by enhancing the incorporation of Se in GPX in the liver (Yin et al, 1991) and GSH by acting as a cofactor in the synthesis of cysteine (Grimble, 1997). The partial protection (total reversal of vitamin C, SOD, CAT, GST and GR and partial reversal of vitamin E, GSH, LPO and GPX) by simultaneous vitamin B6 treatment may be due primarily to its direct oxyradical ; Group IV, vitamin B6 12 h prior to Cr treatment; Group V, vitamin B6 simultaneously with Cr.…”

“…While vitamin B6 deficiency increased oxidative stress (Selvam and Ravichandran, 1991), vitamin B6 supplementation reduced oxidative stress related complications in diabetes and neurodegenerative diseases to varying degrees (Fairfield and Fletcher, 2002;Cohen et al, 1984) and increased GPX and selenium (Se) in erythrocytes and muscles (Yin et al, 1991). Vitamin B6 has also been shown to participate in the maintenance of GSH levels by acting as a cofactor in the synthesis of cysteine (Grimble, 1997).…”

Effect of Energy Compound on Skeletal Muscle Strain Injury and Regeneration in Rats

“…It has been reported that Vit B 6 plays an active part in promoting amino acid metabolism and recovery of peripheral nerve 23) . In other paper, administration of Vit B6 can enhance the utilization of selenium, increase glutathione peroxidase (GSH-Px) activity in erythrocyte, skeletal muscle, myocardium and testis 24) , and decrease lipid peroxides levels 25) . Therefore, Vit B 6 can lessen the damage to cellular structure and promote the regenerative process by reducing the lipid peroxides levels.…”

Pyridoxine Attenuates Chromium‐Induced Oxidative Stress in Rat Kidney

“…Increased oxidative stress with pyridoxine deficiency (Selvam & Ravichandran 1991) and amelioration of oxidative stress with pyridoxine supplementation has previously been reported (Cohen et al 1984; Fairfield & Fletcher 2002). Pyridoxine supplementation has also increased glutathione (GSH) peroxidase and selenium in erythrocytes and muscles (Yin et al 1991) and the synthesis of glutathione by acting as a co‐factor of cysteine synthesis (Grimble 1997). Pyridoxine is a strong quencher of singlet oxygen in fungus, Cercospora nicotiana (Bilski et al 2000) and prevents the oxygen radical generation and lipid peroxidation caused by hydrogen peroxide in U937 monocytes (Kannan & Jain 2004).…”