The Nature of the Arterial Hypertension Produced in Normal Subjects by the Administration of Angiotonin 1

Wilkins, Robert W.; Duncan, Colin

doi:10.1172/jci101266

Cited by 43 publications

(9 citation statements)

References 26 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was also noted by Wilkins and Duncan. 18 These results may be interpreted to indicate that cutaneous vessels constrict, muscular vessels being unaffected by angiotensin. Bock, 30 using a thermal conductivity method, found relatively no change in skin flow during intravenous infusion of angiotensin, although skin flow was markedly re- dueed when angiotension was given intraarterially.…”

Section: Skin Flow and Resistancementioning

confidence: 90%

See 1 more Smart Citation

Effect of Angiotensin Infusion on Regional Blood Flow and Regional Vascular Resistance in the Rat

Mandel

Sapirstein

1962

Circulation Research

View full text Add to dashboard Cite

"4 have been comprehensively reviewed by Page and Bumpus. 5 Although the literature is replete with information on its overall pressor properties and its effects on the cardiac output, the effects of angiotensin on regional blood flow and organ vascular resistance have not been adequately evaluated for most regions. Observations on the regional effects of angiotensin have been confined to a few organs or areas. As will be shown in the Discussion, the results are not always consistent in different preparations, and little information is available in the intact animal.A method developed in the Department of Physiology at Ohio State University 0 allows the measurement of the distribution of the cardiac output to all organs simultaneously in the intact animal. The present report is concerned with the application of this method to the determination of regional blood flow and regional vascular resistance in rats anesthetized with sodium pentobarbital and infused with varying doses of angiotensin. MethodsTwo hundred and eleven female rats of the Sprague-Dawloy strain which had been fasted for 18 hours were used in these studies. Of these, 75 (51 control, 24 experimental) were used in blood From the Department of Physiology, Ohio State Univevsity, Columbus, and Aerospace Medical Laboratory, Wright Patterson Air Force Base, Ohio.This work was supported by grants-in-aid from the American Heart Association and the Central Ohio Heart Association. Support was also received from Grunt H-4730 from the National Heart Institute, U. S. Public Health Service.Dr. Mandol is a Captain (MC) in the United States Air Force. The opinions expressed in this paper are those of the authors and do not necessarily represent the views of the United States Air Force.Received for publication November 27, 1961. pressure measurements; 38 (10 control, 2S expei'iniental) were employed in cardiac output measurements; regional flow distribution for all organs other than the brain was measvii'ed in 71 (22 control, 49 experimental), and cerebral flow fraction was measured in 102 (37 control, 65 experimental). Water wns allowed ad libitum. The animals weighed between 190 and 250 Gm. Sodium pentoharbital (40 mg./Kg., intraperitoneally) was used as the anesthetic. Angiotensin 0 was infused into the femoral vein by means of a Harvard infusion pump for 5 to 25 minutes at 0.05 ml./niin. of solution containing concentrations of angiotensin sufficient to yield 0.05, 0.1, 0.2, 0.3, 0.4, or 0.5 /i.g./Kg. body weight/min.Mean arterial pressures were measured from the femoral artery in heparinized rats with a mercury manometer connected to the artery by a 25-or 27-gauge needle. The same animals were also used for either the cardinc output or the regional flow determination. Cardiac outputs were measured by the indicator-dilution technique, using Rb 80 as the indicator. The rate of sample collection was 60/tnin. Because of the hemorrhage produced by the cardiac output determination, different animals were used for regional blood flow studies.Distribution of blood flo...

show abstract

Section: Skin Flow and Resistancementioning

confidence: 90%

“…Meier- 4 found the blood flow of the hind limbs of animals to be decreased, as did Assali and Westersten, 2 -and Wilkins and Duncan. 18 Schales 14 found forearm blood flow to be unchanged in man after angiotensin. Some of these discrepancies may be due to a possible phasic nature of the response.…”

Section: Carcass Blood Flow and Resistancementioning

confidence: 99%

Effect of Angiotensin Infusion on Regional Blood Flow and Regional Vascular Resistance in the Rat

Mandel

Sapirstein

1962

Circulation Research

View full text Add to dashboard Cite

show abstract

“…In addition, as has been observed by others, venous pressure was elevated to abnormal levels. 7 Finally, normal subjects receiving this drug suffered acutely from abdominal cramps as well as from a peculiar oppressive feeling in the chest that was associated with dyspnea. All of these findings lead to the conclusion that the hypertension induced in the normotensive individual by angiotensin infusion is not akin to essential hypertension as it occurs naturally, although such a conclusion must be tempered by a realization of the acute nature of the experiments.…”

Section: Circulation Research Volume IX May 1961mentioning

confidence: 99%

Peripheral Venous and Arteriolar Responses to Infusions of Angiotensin in Normal and Hypertensive Subjects

Wood

1961

Circulation Research

View full text Add to dashboard Cite

The distensibility of the peripheral veins of the hypertensive subject is normal, that is, there is no evidence of peripheral venoconstriction, despite the excessive arteriolar constriction. The forearm veins of hypertensive patients respond to pooling of blood in the upright position to a lesser degree than do veins of normotensive individuals, indicating a lesser degree of smypathetic nervous activity in response to this stimulus. The peripheral veins of hypertensive subjects constrict normally in response to an infusion of norepinephrine, indicating that failure of venoconstriction in any circumstance cannot be attributed to failure of the smooth muscle of the veins. Infusions of angiotensin produce constriction of the veins as well as the arterioles in normotensive individuals thus failing to mimic the naturally occurring state of essential hypertension. Infusions of angiotensin in hypertensive patients result in further arteriolar constriction and hypertension without concomitant venoconstriction. The results of these experiments suggest that peripheral venous responses of hypertensive subjects to angiotensin infusions may have been modified by previous exposure of these vessels to a material at least similar to angiotensin.

show abstract

“…Both agents produce arteriolar constriction (20)(21)(22)(23)(24)33), but norepinephrine also causes venoconstriction that decreases the peripheral vascular capacity (34, 35), whereas angiotensin lacks significant venoconstrictor effect (36)(37)(38). Contractile force of the heart is markedly augmented by norepinephrine (39,40), but many investigators have suggested that angiotensin is essentially devoid of myocardial stimulating properties (21,23,(41)(42)(43)(44). In the isolated heart and heart-lung preparation, however, angiotensin has a prominent inotropic effect (26,(45)(46)(47)(48).…”

Section: Angiotensinmentioning

confidence: 99%

Studies in Clinical Shock and Hypotension. II. Hemodynamic Effects of Norepinephrine and Angiotensin*

Cohn¹,

Luria²

1965

J. Clin. Invest.

View full text Add to dashboard Cite

The Nature of the Arterial Hypertension Produced in Normal Subjects by the Administration of Angiotonin 1

Cited by 43 publications

References 26 publications

Effect of Angiotensin Infusion on Regional Blood Flow and Regional Vascular Resistance in the Rat

Effect of Angiotensin Infusion on Regional Blood Flow and Regional Vascular Resistance in the Rat

Peripheral Venous and Arteriolar Responses to Infusions of Angiotensin in Normal and Hypertensive Subjects

Studies in Clinical Shock and Hypotension. II. Hemodynamic Effects of Norepinephrine and Angiotensin*

Contact Info

Product

Resources

About