The natural history of periodontal disease in humans: risk factors for tooth loss in caries‐free subjects receiving no oral health care

Abstract

Aim: No long‐term studies have reported on risk factors for tooth loss in subjects without home or professional dental care. The purpose of this report is to identify potential risk factors for tooth loss among male Sri Lankan tea labourers who participated in a 20‐year investigation of the natural history of periodontal disease. Material and Methods: Data for this report were obtained from the 455 subjects who participated in multiple examinations over the 20‐year period from 1970 to 1990. Analyses included data from interim examinations in 1971, 1973, 1977, 1982 and 1985. Oral health assessments included the following: (1) attachment levels in millimetres on all mesial and mesio‐buccal surfaces, excluding third molars; (2) plaque index; (3) gingival index; (4) calculus index; (5) caries index; and (6) missing teeth. Other variables included age, history of smoking and betel nut use. Statistical analyses included descriptive statistics and multivariate repeated‐measures modelling with generalized estimating equations. Results: Tooth loss was significantly dependent upon interactions between the mean attachment loss and betel nut use (Z=3.40; p=0.0007) and history of missing teeth (Z=−3.70; p=0.0002). The effect of attachment loss on tooth loss was increased in the presence of betel nut and diminished when teeth were already missing at baseline. Conclusion: History of missing teeth, betel nut use and increasing attachment loss were significant predictors of tooth loss over time. Betel nut use increased the effect of attachment loss on loss of teeth, while history of missing teeth diminished the effect of attachment loss on tooth loss.

The Hemoglobin Receptor Protein ofPorphyromonas gingivalisInhibits Receptor Activator NF-κB Ligand-Induced Osteoclastogenesis from Bone Marrow Macrophages

“…Periodontal diseases are chronic inflammatory conditions of supporting tissues of teeth affecting the majority of adult human population (32,34). Alveolar bone resorption is a major clinical characteristic of periodontitis including chronic adult periodontitis (44).…”

Prevalência De Perda De Dentes Permanentes Em Pacientes Que Procuram Tratamento Odontológico Na Disciplina De Clínica Integrada Do Curso De Odontologia Da Uepg

“…Foi verificado que, com o aumento da idade, também existiu um maior número de dentes perdidos. Esse fato pode ser confirmado em vários estudos (ROSA et al, 1992;PERES et al, 2013;BATISTA et al, 2015). Segundo Rosa et al (1992), os pacientes que possuem um grande número de dentes ausentes acham "normal" a perda dentária com o avanço da idade, e, ainda, não se mostram preocupados em fazer uma reabilitação protética ou com implantes.…”

“…Além destas, somam-se atitudes precipitadas de profissionais da Odontologia, dificuldade na acessibilidade e utilização de serviços odontológicos do sistema de saúde além de motivos de ordem econômica (NEELY et al, 2005;BROADBENT et al, 2006, BARBATO;PERES, 2009;BAHRAMI et al, 2008;TRAMINI et al, 2007;EICKHOLZ et al, 2008). Apesar de serem problemas de saúde pública, as perdas dentárias vêm sendo pouco investigadas no Brasil.…”

“…As perdas dentárias constituem-se, entre outros fatores, uma marca da desigualdade social, diminuem a função mastigatória dificultando e limitando o consumo de diversos alimentos, causando, dessa maneira, danos ao organismo de ordem nutricional. Além disso, afetam a fonação e causam danos estéticos que podem originar alterações psicológicas (BUCCA et al, 2006;GRABE et al, 2009;NEELY et al, 2005;SUSIN et al, 2006;JIMENEZ et al, 2009;NASSANI et al, 2009).…”

Lipopolysaccharide biosynthesis-related genes are required for colony pigmentation of Porphyromonas gingivalis

“…Periodontal disease, the major cause of tooth loss in the general populations of industrial nations, is a chronic inflammatory disease of the periodontium (Neely et al, 2005;Oliver et al, 1998). The obligately anaerobic Gram-negative bacterium Porphyromonas gingivalis, a major causative agent of chronic periodontitis, possesses several potential virulence factors for periodontopathogenicity (Holt et al, 1999;Lamont & Jenkinson, 2000).…”