2000
DOI: 10.1001/jama.284.4.450
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Abstract: Our results indicate that although HCV infection can be self-limited or associated with ESLD, the majority of adults have persistent viremia without clinically demonstrable liver disease. Further research is needed to explain the less frequent clearance of HCV infection among black persons and to improve utilization of treatment for those infected in the context of injection drug use. JAMA. 2000;284:450-456

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Cited by 983 publications
(777 citation statements)
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“…HCV infection is cleared less frequently in the elderly and African-Americans (compared with other races). End-stage liver disease is more common in HCVπ patients over the age of 38 (17). The present analysis confirmed risk factors for HCV of African-American race, male gender, and age in the renal transplant population.…”
Section: Discussionsupporting
confidence: 79%
“…HCV infection is cleared less frequently in the elderly and African-Americans (compared with other races). End-stage liver disease is more common in HCVπ patients over the age of 38 (17). The present analysis confirmed risk factors for HCV of African-American race, male gender, and age in the renal transplant population.…”
Section: Discussionsupporting
confidence: 79%
“…These factors were chosen because HIV status and race are determinants of viral clearance. 7 For HBV, cases were persistently infected with HBV and matched to two controls from the same cohort based on factors that have been associated with HBV outcomes, including age within 10 years, gender, and HIV type-1 (HIV-1) status. Subjects were considered persistently infected with HBV if they tested positive for hepatitis B surface antigen (HBsAg) at two visits separated by a minimum of 6 months.…”
Section: Study Participantsmentioning
confidence: 99%
“…5,6 In addition, recovery from HCV infection occurs more often in Caucasians than African Americans, even after adjusting for environmental and viral factors. 7 Some host genetic polymorphisms in the human leukocyte antigen complex have been associated with HCV recovery. 8,9 However, much of the genetic basis for viral recovery remains unknown.…”
Section: Introductionmentioning
confidence: 99%
“…1 HCV clearance is known to occur less often in blacks people, alcohol users, and HIVinfected persons. 7,8 In the chronic state, the infection may progress to cirrhosis with the subsequent development of complications such as ascites, encephalopathy, variceal bleeding, and hepatocellular carcinoma because of the continual inflammatory response to the viral infection. As many as 75% of HCV-positive patients in the United States have the chronic form of HCV infection, 3 most of which will develop chronic hepatitis and progressive fibrosis.…”
Section: Introductionmentioning
confidence: 99%