1993
DOI: 10.1212/wnl.43.7.1316
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Abstract: Using 42 strength and functional assessments recorded monthly, the natural history of amyotrophic lateral sclerosis (ALS) is described in 167 patients (98 men, 67 women) followed in five medical centers in the western United States. The mean age at onset was 57.4 years, and symptoms were present for 2.64 years before study entry. Although there was a highly variable rate of decline within the group of patients, there were no differences in rate of decline by age or gender. Older patients and women were weaker … Show more

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Cited by 202 publications
(119 citation statements)
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“…Patients can present with bulbar onset disease (approximately 25% of cases), limb onset disease (approximately 70% of cases) or initial trunk or respiratory involvement (approximately 5% of cases) subsequently spreading to other regions (3). Almost half of all patients with ALS die within three years of onset, primarily due to respiratory failure (4,5).…”
Section: Introductionmentioning
confidence: 99%
“…Patients can present with bulbar onset disease (approximately 25% of cases), limb onset disease (approximately 70% of cases) or initial trunk or respiratory involvement (approximately 5% of cases) subsequently spreading to other regions (3). Almost half of all patients with ALS die within three years of onset, primarily due to respiratory failure (4,5).…”
Section: Introductionmentioning
confidence: 99%
“…Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder characterized by rapid deterioration and selective death of motor neurons (MNs) in the cerebral cortex, brain stem, and spinal cord [1][2][3]. Clinical features are attributable to the superimposition of motor deficits occurring in the upper motor neuron (UMN) and lower motor neuron (LMN).…”
Section: Introductionmentioning
confidence: 99%
“…Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder characterized by rapid deterioration and the selective death of motor neurons (MN) in the cerebral cortex, brain stem, and spinal cord [1][2][3]. A wide variety of clinical manifestations are present early in the course of ALS [4].…”
Section: Introductionmentioning
confidence: 99%