The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells

Shendge, Anil Khushalrao; Chaudhuri, Dipankar; Mandal, Nripendranath

doi:10.1007/s11033-020-06087-x

Cited by 34 publications

(17 citation statements)

References 49 publications

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“…This difference in activity may also be related to the methylation of the hydroxyl group at C4', since this modification was shown to have a different effect depending on cell type. 53,55,58 To conclude, the negative influence of the hydroxyl group at C3 is, at least in part, removed by methylation. Additionally, like cirsimaritin, santin is C6-methoxylated.…”

Section: Discussionmentioning

confidence: 96%

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Szoka

Nazaruk

Stocki

et al. 2021

J Cellular Molecular Medi

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Numerous studies provide evidence for the potential beneficial effect of flavonoids in cancer chemoprevention and inducing cancer cell death. 1,2 Flavonoids are low molecular weight, secondary plant metabolites characterized by a benzoγ-pyrone core. This broad class of phenolics contains over 4000 compounds. 3 Due to their wide distribution in the leaves, flowers, fruits, bark and seeds of plants, flavonoids are part of human diet and herbal medicine. Flavonoids occur in plant cells primarily as glycosides and polymers that need to be degraded before absorption. 4 Hydrolysis of flavonoid glycosides is catalysed by small intestine hydrolases and human intestinal microflora. Absorbed aglycones are metabolized by glucuronidation, sulfation and O-methylation in enterocytes, or transported with subsequent conjugation in the liver. Consequently, orally administered flavonoids reach the highest concentration and thus exert the most potent effect in the digestive tract and liver. Downy birch (Betula pubescens Ehrh.) and silver birch (Betula pendula Roth) are deciduous trees characterized by their silver-white bark.Downy birch commonly grows in Europe and northern Asia, particularly in damp soils, while silver birch prefers less moist soils. 5 Dried fresh leaves of both birch species are used in Polish traditional medicine as a diuretic. 6 The major constituents of the leaves that probably cause the diuretic effect are flavonoids, hyperoside and other

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Section: Discussionmentioning

confidence: 96%

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Szoka

Nazaruk

Stocki

et al. 2021

J Cellular Molecular Medi

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“…Both the pathways converge to cleave polymer adenosine diphosphate ribose (PARP), which leads to DNA damage, induced cell death mechanisms [ 10 ]. The deregulation of cell-cycle proteins can lead to uncontrolled cell growth and spread, which eventually initiates tumor growth [ 11 ]. Flavonoids exhibit suppressed proliferation rate of cancer cells through the induction of cell cycle arrest [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells

Bhosale

Vetrivel

et al. 2021

Molecules

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Iridin is a natural flavonoid found in Belamcanda chinensis documented for its broad spectrum of biological activities like antioxidant, antitumor, and antiproliferative effects. In the present study, we have investigated the antitumor potential of iridin in AGS gastric cancer cells. Iridin treatment decreases AGS cell growth and promotes G2/M phase cell cycle arrest by attenuating the expression of Cdc25C, CDK1, and Cyclin B1 proteins. Iridin-treatment also triggered apoptotic cell death in AGS cells, which was verified by cleaved Caspase-3 (Cl- Caspase-3) and poly ADP-ribose polymerase (PARP) protein expression. Further apoptotic cell death was confirmed by increased apoptotic cell death fraction shown in allophycocyanin (APC)/Annexin V and propidium iodide staining. Iridin also increased the expression of extrinsic apoptotic pathway proteins like Fas, FasL, and cleaved Caspase-8 in AGS cells. On the contrary, iridin-treated AGS cells did not show variations in proteins related to an intrinsic apoptotic pathway such as Bax and Bcl-xL. Besides, Iridin showed inhibition of PI3K/AKT signaling pathways by downregulation of (p-PI3K, p-AKT) proteins in AGS cells. In conclusion, these data suggest that iridin has anticancer potential by inhibiting PI3K/AKT pathway. It could be a basis for further drug design in gastric cancer treatment.

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“…Notably, cyclin B1/CDK1 is pivotal in regulating mitochondrial metabolism in tumors. Among all the subunits of mitochondrial respiration chain (complex I-V), 12 subunits, including eight complex I subunits (NADH ubiquinone oxidoreductase), can be potentially phosphorylated by cyclin B1/CDK1, indicating that cyclin B1/CDK1 is involved in controlling ATP output and triggering ROS generation (41,57).…”

Section: Discussionmentioning

confidence: 99%

Luteolin potentiates low‑dose oxaliplatin‑induced inhibitory effects on cell proliferation in gastric cancer by inducing G2/M cell cycle arrest and apoptosis

Chen

Zhu

et al. 2021

Oncol Lett

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The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells

Cited by 34 publications

References 49 publications

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Santin and cirsimaritin from Betula pubescens and Betula pendula buds induce apoptosis in human digestive system cancer cells

Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells

Luteolin potentiates low‑dose oxaliplatin‑induced inhibitory effects on cell proliferation in gastric cancer by inducing G2/M cell cycle arrest and apoptosis

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