The nano-Au self-assembled glassy carbon electrode for selective determination of epinephrine in the presence of ascorbic acid

Yang, Zhousheng; Hu, Guangzhi; Chen, Xi; Zhao, Jun; Zhao, Guang‐Chao

doi:10.1016/j.colsurfb.2006.10.033

Cited by 93 publications

(54 citation statements)

References 34 publications

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“…The linear regression equation of E pa /V ¼ 0.641 À 0.068 pH was obtained (correlation coefficient r ¼ 0.998). The slope value is close to the theoretical Nernstian value of 0.059 V indicating that the number of protons and electrons involved are equal [28,34]. Figure 3 also reveals that the i pa increases with increase in pH up to 7.0 and further increase of pH results in the decrease of anodic peak current.…”

Section: à2supporting

confidence: 70%

“…, which was higher than the reported D o value for EP at L-cysteine and gold nanoparticles modified gold electrodes [31,34,35]. This reveals that at the present modified electrode, the oxidation of EP occurs at faster rate and hence higher oxidation current was observed.…”

contrasting

confidence: 76%

“…Among the different methods, electrochemical method has the advantage of simplicity, high sensitivity and selectivity. Electrodes modified with singlewalled carbon nanotubes [27], overoxidized dopamine [28], caffeic acid [29], SAMs of 3-mercaptopropionic acid [30], L-cysteine [31], homocysteine [32] and triazole [33] and gold nanoparticles [34,35] were used for the determination of EP. Although numerous electrochemical sensors for EP have been published in the literature fabrication of economically viable electrochemical sensor with higher selectivity, stability and sensitivity is still one of the challenging tasks for the electrochemists.…”

Section: Introductionmentioning

confidence: 99%

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Selective Electrochemical Epinephrine Sensor Using Self‐Assembled Monomolecular Film of 1,8,15,22‐Tetraaminophthalocyanatonickel(II) on Gold Electrode

Sivanesan

John

2008

Electroanalysis

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This article describes the highly sensitive and selective determination of epinephrine (EP) using self-assembled monomolecular film (SAMF) of 1,8,15,22-tetraamino-phthalocyanatonickel(II) (4a-Ni II TAPc) on Au electrode. The 4a-Ni II TAPc SAMF modified electrode was prepared by spontaneous adsorption of 4a-Ni II TAPc from dimethylformamide solution. The modified electrode oxidizes EP at less over potential with enhanced current response in contrast to the bare Au electrode. The standard heterogeneous rate constant (k8) for the oxidation of EP at 4a-Ni II TAPc SAMF modified electrode was found to be 1.94 Â 10 À2 cm s À1 which was much higher than that at the bare Au electrode. Further, it was found that 4a-Ni II TAPc SAMF modified electrode separates the voltammetric signals of ascorbic acid (AA) and EP with a peak separation of 250 mV. Using amperometric method the lowest detection limit of 50 nM of EP was achieved at SAMF modified electrode. Simultaneous amperometric determination of AA and EP was also achieved at the SAMF modified electrode. Common physiological interferents such as uric acid, glucose, urea and NaCl do not interfere within the potential window of EP oxidation. The present 4a-Ni II TAPc SAMF modified electrode was also successfully applied to determine the concentration of EP in commercially available injection.

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Section: à2supporting

confidence: 70%

contrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Selective Electrochemical Epinephrine Sensor Using Self‐Assembled Monomolecular Film of 1,8,15,22‐Tetraaminophthalocyanatonickel(II) on Gold Electrode

Sivanesan

John

2008

Electroanalysis

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“…The epinephrine electrooxidation at bare electrode is associated with problems of slow electron transfer rate and adsorptions of epinephrine on the electrode surfaces leading to passivation [20]. Electrochemical methods for epinephrine analysis making use of modified carbon electrodes [14 -19], carbon nanotubes [20,21] and gold nanoparticles modified electrodes [14,22,23] have been reported. The major challenge in epinephrine analysis is the elimination of interferences from ascorbic acid; ascorbic acid oxidation peak is very close to that of epinephrine which often results to their peaks overlapping.…”

Section: Introductionmentioning

confidence: 99%

Efficient Electrocatalytic Detection of Epinephrine at Gold Electrodes Modified with Self‐Assembled Metallo‐Octacarboxyphthalocyanine Complexes

Agboola

Ozoemena

2008

Electroanalysis

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Electrocatalysis of epinephrine at gold electrode pre-modified with the self-assembled monolayer of cysteamine and subsequently integrated with novel metallo-octacarboxyphthalocyanine (MOCPc where M ¼ Fe, Co and Mn) complexes (Au-Cys-MOCPc) was investigated. The electrodes showed response to the presence of epinephrine. The oxidation peak potential (E p /V vs. Ag j AgCl, satd KCl) and charge transfer resistance (R ct (kW)) in epinephrine solution depend markedly on the central metal of the phthalocyanine cores: Au-Cys-FeOCPc < Au-Cys-MnOCPc < Au-Cys-CoOCPc. All the electrodes showed first order electrode kinetics in [epinephrine]; the Au-Cys-FeOCPc electrode exhibited catalytic rate constant () which is higher than that of the Au-cys-CoOCPc or Au-cys-MnOCPc electrode. Mechanism, recognizing the mediation of the electrocatalytic process by the central M(II)/M(III) redox processes was proposed. Epinephrine electro-oxidation at the Au-cys-FeOCPc electrode was studied in more details for the response characteristics. The diffusion coefficient of epinephrine was evaluated as (2.62 AE 0.23) Â 10 À9 cm 2 s À1. It was established that Au-Cys-FeOCPc is suitable for sensitive determination of epinephrine in physiological pH (7.40) conditions showing linear concentration range of up to 300 nM, with excellent sensitivity (0.53 AE 0.01 nA nM À1 ), and very low limits of detection (13.8 nM) and quantification (45.8 nM). The peak separation between ascorbic acid and epinephrine is large enough (190 mV) to permit simultaneous determination of both epinephrine and ascorbic acid in physiological pH 7.4 conditions using the Au-cys-FeOCPc electrode. Au-cysFeOCPc electrode was successfully used for the determination of epinephrine in epinephrine hydrochloric acid injection with recovery of ca. 98.4%.

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“…From the point of view of medicine, it is a drug for emergency treatment in severe allergic reaction, cardiac arrest and sepsis [23]. Therefore, the quantitative determination of EP concentration in different human fluids, such as plasma and urine, is important for developing nerve physiology, pharmacological research and life science [24].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Studies of Paracetamoland Folic Acid in the Presence of Epinephrineat Poly (Eosin) Modified Electrode: A Voltammetric Study

Cm¹,

Be²,

Jayadevappa³

2017

J Biosens Bioelectron

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The nano-Au self-assembled glassy carbon electrode for selective determination of epinephrine in the presence of ascorbic acid

Cited by 93 publications

References 34 publications

Selective Electrochemical Epinephrine Sensor Using Self‐Assembled Monomolecular Film of 1,8,15,22‐Tetraaminophthalocyanatonickel(II) on Gold Electrode

Selective Electrochemical Epinephrine Sensor Using Self‐Assembled Monomolecular Film of 1,8,15,22‐Tetraaminophthalocyanatonickel(II) on Gold Electrode

Efficient Electrocatalytic Detection of Epinephrine at Gold Electrodes Modified with Self‐Assembled Metallo‐Octacarboxyphthalocyanine Complexes

Electrochemical Studies of Paracetamoland Folic Acid in the Presence of Epinephrineat Poly (Eosin) Modified Electrode: A Voltammetric Study

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