The nail in Darier-White disease

Isolated Congenital Nail Dysplasia

“…13 In our family, only the nail changes vaguely resembled Darier disease, and none of the affected members had skin changes consistent with this genodermatosis. Histopathological criteria typical of Darier disease, such as suprabasal clefts containing acantholytic cells in the dorsal portion of the proximal nail fold and the nail matrix and multinucleate epithelial giant cells in the cornified cells of the nail bed and nail plate, 14 were not detectable in the biopsy specimens of our patients.…”

“…Male patients proved to be, on average, more severely affected than female patients (median score, 10 vs 7), which is explained at least in part by the less intensive V-shaped lunula of individual nails 3 (14) and less regular nail care performed by the male patients. Children younger than 12 years had slightly more severe nail changes than adolescents and adults (median scores, 10, 9, and 9, respectively).…”

Isolated Congenital Nail Dysplasia

“…13 In our family, only the nail changes vaguely resembled Darier disease, and none of the affected members had skin changes consistent with this genodermatosis. Histopathological criteria typical of Darier disease, such as suprabasal clefts containing acantholytic cells in the dorsal portion of the proximal nail fold and the nail matrix and multinucleate epithelial giant cells in the cornified cells of the nail bed and nail plate, 14 were not detectable in the biopsy specimens of our patients.…”

“…Male patients proved to be, on average, more severely affected than female patients (median score, 10 vs 7), which is explained at least in part by the less intensive V-shaped lunula of individual nails 3 (14) and less regular nail care performed by the male patients. Children younger than 12 years had slightly more severe nail changes than adolescents and adults (median scores, 10, 9, and 9, respectively).…”

Photo-Onycholysis Induced by 8-Methoxypsoralen

“…In the nail bed of patients with Darier-White disease, multinucleate cells with as many as 20 nuclei/cell were detected [21]. From the case histories of both patients studied in this paper, this disease could be excluded.…”

Localized Longitudinal Erythronychia

“…In Darier disease, the primary abnormality is thought to be within the matrix. 2 This observation supports attributing the distal keratosis to a primary matrix process, although the mechanism whereby this happens is not clear. Multinucleated cells are often seen in the distal nail bed in Darier disease, subungual warty dyskeratoma, and onychopapilloma, 3 which indicates that it might be a nonspecific response.…”

Isolated Congenital Nail Dysplasia

“…13 In our family, only the nail changes vaguely resembled Darier disease, and none of the affected members had skin changes consistent with this genodermatosis. Histopathological criteria typical of Darier disease, such as suprabasal clefts containing acantholytic cells in the dorsal portion of the proximal nail fold and the nail matrix and multinucleate epithelial giant cells in the cornified cells of the nail bed and nail plate, 14 were not detectable in the biopsy specimens of our patients.…”

“…Male patients proved to be, on average, more severely affected than female patients (median score, 10 vs 7), which is explained at least in part by the less intensive V-shaped lunula of individual nails 3 (14) and less regular nail care performed by the male patients. Children younger than 12 years had slightly more severe nail changes than adolescents and adults (median scores, 10, 9, and 9, respectively).…”

Photo-Onycholysis Induced by 8-Methoxypsoralen

“…In the nail bed of patients with Darier-White disease, multinucleate cells with as many as 20 nuclei/cell were detected [21]. From the case histories of both patients studied in this paper, this disease could be excluded.…”

Localized Longitudinal Erythronychia

“…In Darier disease, the primary abnormality is thought to be within the matrix. 2 This observation supports attributing the distal keratosis to a primary matrix process, although the mechanism whereby this happens is not clear. Multinucleated cells are often seen in the distal nail bed in Darier disease, subungual warty dyskeratoma, and onychopapilloma, 3 which indicates that it might be a nonspecific response.…”

Isolated Congenital Nail Dysplasia

“…13 In our family, only the nail changes vaguely resembled Darier disease, and none of the affected members had skin changes consistent with this genodermatosis. Histopathological criteria typical of Darier disease, such as suprabasal clefts containing acantholytic cells in the dorsal portion of the proximal nail fold and the nail matrix and multinucleate epithelial giant cells in the cornified cells of the nail bed and nail plate, 14 were not detectable in the biopsy specimens of our patients.…”

“…Male patients proved to be, on average, more severely affected than female patients (median score, 10 vs 7), which is explained at least in part by the less intensive V-shaped lunula of individual nails 3 (14) and less regular nail care performed by the male patients. Children younger than 12 years had slightly more severe nail changes than adolescents and adults (median scores, 10, 9, and 9, respectively).…”

Photo-Onycholysis Induced by 8-Methoxypsoralen

“…In the nail bed of patients with Darier-White disease, multinucleate cells with as many as 20 nuclei/cell were detected [21]. From the case histories of both patients studied in this paper, this disease could be excluded.…”

Localized Longitudinal Erythronychia

“…In Darier disease, the primary abnormality is thought to be within the matrix. 2 This observation supports attributing the distal keratosis to a primary matrix process, although the mechanism whereby this happens is not clear. Multinucleated cells are often seen in the distal nail bed in Darier disease, subungual warty dyskeratoma, and onychopapilloma, 3 which indicates that it might be a nonspecific response.…”