The Myotrophic and Androgenic Effects of 17-Ethyl-19-Nortestosterone and Related Compounds

Clinical and Physiological Observations in a Patient With an Idiopathic Decrease in the Thyroxine-Binding Globulin of Plasma*

“…It appeared possible, however, that the patient's abnormal testes were secreting an unusual, nonandrogenic steroid capable of decreasing TBG. Apparently the capacity of certain steroids to decrease TBG is not a function of their androgenic potency, since norethandrolone,10 a steroid with relatively more anabolic than androgenic activity (22), has proved capable of inducing pronounced reductions in TBG within a period as short as 1 week (23). During this time fractional peripheral turnover of T4 was accelerated, but androgenic effects were not evident, even in hypogonadal patients (23).…”

COUNTERACTION BETWEEN ESTROGENIC AND PROGESTATIONAL PROPERTIES OF 17α-Ethinyl-19-Nortestosterone

“…A) 17a-Ethinyl-19-nortestosterone It has been demonstrated by many workers that 17a-ethinyl-19-nortestosterone has a high progestational activity and a low but definite estrogenic potency, being almost totally lacking in androgenic and myotrophic properties (Hertz et al, 1954(Hertz et al, , 1956Pincus et al, 1956;Saunders et al, 1956;Dusan et al, 1956;Ferin, 1956;Greenblatt, 1956;Tullner et al, 1957;Kaiser, 1957;Miyake et al, 1958 Injections of the largest dose, 2mg daily, resulted in an unexpected vaginal reaction (Fig. 1, E-3). Estrus was also induced by this dose as by smaller doses (E-1 and E-2) but in a few days vaginal index fell rapidly and on the 6th and 7th day the animals were almost in anestrous state (average indices 0.5 and 0.9, respectively).…”

“…Subsequently, however, vaginal index rose gradually in rats given 2mg daily and on the 11th or 12th day, all the animals showed fully cornified smears again(indices 5.0). B) 17a-Methyl-19-nortestosterone Although progestational activity of 17a-methyl-19-nortestosterone is comparable to that of 17a-ethinyl-l9-nortestosterone (Pincus et al, 1956;Ferin, 1956;Overbeek and Visser, 1956;Lutwak-Mann et al, 1957;Kaiser, 1957;Miyake et al, 1958), it possesses scarcely any estrogenic potency (Saunders and Drill, 1956;Pincus et al, 1956 Studies of biological actions of highly purified material have revealed that it has an estrogenic activity less than 0.3% of that of estrone and a hypophyseal inhibitory capacity, less than 0.1% (Maekawa, unpublished). Progestational activity is about 10% of that of progesterone(Ando, Kobayashi and Nakano, personal communication).…”

Estradienes and 2-Oxaestradienes. Potent Oral Anabolic-Androgenic Agents

“…Androgenic and myotrophic responses were determined by the method of Eisenberg and Gordan (1) as modified by Saunders and Drill (2). Briefly, 43-day-old male rats (Badger Research, Inc., Madison, Wise), castrated 3 weeks previously, were treated daily for 7 days with 1/7 of the total dose of compound, dissolved in 0.2 ml corn oil and administered orally by stomach catheter.…”