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Abstract: Caveolae are a highly abundant but enigmatic feature of mammalian cells. They form remarkably stable membrane domains at the plasma membrane but can also function as carriers in the exocytic and endocytic pathways. The apparently diverse functions of caveolae, including mechanosensing and lipid regulation, might be linked to their ability to respond to plasma membrane changes, a property that is dependent on their specialized lipid composition and biophysical properties.

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Cited by 1,214 publications
(1,193 citation statements)
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“…To determine whether 3D8 scFv in caveolae/caveosomes is transported to endoplasmic reticulum (ER) and/or Golgi before its cytosolic accumulation, time-course chase of 3D8 scFv was Research Article 1991 carried out with the subcellular organelle markers; calnexin for ER and 58K Golgi protein for Golgi. As shown in Figure 6A, 3D8 scFv was not colocalized with both ER and Golgi markers for up to 12 h of trafficking, whereas control Ctx-B, which is known to translocate to ER from caveosomes [13], overlapped with the ER marker within 2 h of trafficking (Fig. 6B).…”
Section: Resultsmentioning
confidence: 79%
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“…To determine whether 3D8 scFv in caveolae/caveosomes is transported to endoplasmic reticulum (ER) and/or Golgi before its cytosolic accumulation, time-course chase of 3D8 scFv was Research Article 1991 carried out with the subcellular organelle markers; calnexin for ER and 58K Golgi protein for Golgi. As shown in Figure 6A, 3D8 scFv was not colocalized with both ER and Golgi markers for up to 12 h of trafficking, whereas control Ctx-B, which is known to translocate to ER from caveosomes [13], overlapped with the ER marker within 2 h of trafficking (Fig. 6B).…”
Section: Resultsmentioning
confidence: 79%
“…Next, we carried out knock-down experiments of genes involved in the caveolae/lipid raft-mediated endocytosis using siRNA techniques. Caveolin-1 (cav-1) is an essential component for both the structure and function of caveolae, called a specialized lipid rafts containing caveolin [13]. To verify caveolin-dependency of 3D8 scFv endocytosis, HeLa cells were transfected with cav-1 siRNA or control siRNAs (clathrin-or scramble siRNA), and incubated with 3D8 scFv for 2 h after 48 h of transfection.…”
Section: Resultsmentioning
confidence: 99%
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