2014
DOI: 10.1016/j.semcancer.2014.08.003
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Abstract: Cripto-1 (CR-1)/Teratocarcinoma-derived growth factor1 (TDGF-1) is a cell surface glycosylphosphatidylinositol (GPI)-linked glycoprotein that can function either in cis (autocrine) or in trans (paracrine). The cell membrane cis form is found in lipid rafts and endosomes while the trans acting form lacking the GPI anchor is soluble. As a member of the epidermal growth factor (EGF)/Cripto-1-FRL-1-Cryptic (CFC) family, CR-1 functions as an obligatory co-receptor for the transforming growth factor-β (TGF-β) family… Show more

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Cited by 87 publications
(94 citation statements)
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“…However, it is interesting to note that some of the other Bicc1 mRNA targets we identified in our previous studies have also been implicated as modulators of Wnt signaling. For example, we have shown that cripto1 mRNA is a Bicc1 target, and the Cripto1 protein affects multiple signaling events, including those of the Wnt pathway (Nagaoka et al, 2012(Nagaoka et al, , 2013Klauzinska et al, 2014). We also identified ddx5 mRNA as a Bicc1 target (Zhang et al, 2013), and Ddx proteins are documented modulators of Wnt signaling (Cruciat et al, 2013).…”
Section: Post-transcriptional Control Of Wnt Signalingmentioning
confidence: 88%
“…However, it is interesting to note that some of the other Bicc1 mRNA targets we identified in our previous studies have also been implicated as modulators of Wnt signaling. For example, we have shown that cripto1 mRNA is a Bicc1 target, and the Cripto1 protein affects multiple signaling events, including those of the Wnt pathway (Nagaoka et al, 2012(Nagaoka et al, , 2013Klauzinska et al, 2014). We also identified ddx5 mRNA as a Bicc1 target (Zhang et al, 2013), and Ddx proteins are documented modulators of Wnt signaling (Cruciat et al, 2013).…”
Section: Post-transcriptional Control Of Wnt Signalingmentioning
confidence: 88%
“…It is a cell surface GPI-linked glycoprotein and a member of the epidermal growth factor/ Cripto-1-FRL-1-Cryptic family [29]. TDGF-1 is an obligatory coreceptor for the transforming growth factor-β pathway by activating the Alk4/Alk7 signaling pathways [28].…”
Section: Discussionmentioning
confidence: 99%
“…Remarkably, it is expressed in CSCs compartments, modulating and boosting cancer cell proliferation, migration, invasion, epithelial mesenchymal transition (EMT) and angiogenesis (Klauzinska et al, 2014).…”
Section: Issn: 2320-5407mentioning
confidence: 99%