The mucilage of the roots of clossostemon bruguieri (moghat)

Amin, El S.; Awad, Olfat

doi:10.1016/s0008-6215(00)81428-7

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…After childbirth, women have especially used hot drinks of powdered Moghat as a general tonic and lactagogue. Due to its high content of mucilage (up to 27% based on dry weight) [ 2 , 4 , 5 , 6 ], Moghat is also prescribed as a demulcent agent. Previous work on the chemistry of the compounds produced from Moghat indicated the presence of oestrone [ 2 , 7 ], scopoletin, phytosterols (a mixture of β-sitosterol, stigmasterol and campesterol) [ 2 , 8 ], α-amyrin, and glucosides of flavone and chalcone [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Constituents from Moghat, the Roots of Glossostemon bruguieri (Desf.)

Meselhy

2003

Molecules

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The new biflavone moghatin (3″′-hydroxycupressuflavone) was isolated from Moghat, the dried peeled roots of Glossostemon bruguieri (Desf.), together with five known compounds: 4′-methoxyisoscutellargin, sesamin, chrysophanol, emodin and methoxyemodin (physcion). The structures of these compounds were assigned on the basis of spectroscopic data. Occurrence of these compounds in Moghat is reported here for the first time.

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Section: Introductionmentioning

confidence: 99%

Constituents from Moghat, the Roots of Glossostemon bruguieri (Desf.)

Meselhy

2003

Molecules

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“…It is considered as a remarkable food supplement and possesses significant hypoglycemic activity [9]. On the basis of dry matter, moghat roots contain 35% mucilage, 24% starch, 5.5% protein, 5% fats, 5% pectin, 3% sugars, and amino acids (majorly aspartic and glutamic acids) [25]. They also contain major minerals (calcium, iron, and magnesium) and minor minerals (zinc, copper, and manganese), as well as high amounts of oleic and linolenic acids [11].…”

Section: Discussionmentioning

confidence: 99%

Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells

Alwahibi

Khalil

Ibrahim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Glossostemon bruguieri (moghat) is used as a nutritive and demulcent drink. This study was performed to investigate the antiproliferative effects of moghat root extract (MRE) and its apoptotic mechanism in hepatocellular carcinoma (HCC) cells, HepG2 and Hep3B. MTT assay, morphological changes, apoptosis enzyme linked immunosorbent assay, caspase and apoptotic activation, flow cytometry, and immunoblot analysis were employed. The IC50 of MRE for HepG2 (910 ± 6 μg/ml) and for Hep3B (1510 ± 5 μg/ml) induced significant growth-inhibitory effects against HCC cells, with no cytotoxic effect on normal hepatocytes. MRE treatment induced apoptotic effects to HepG2 cells in a caspase-dependent manner and via upregulating p53/p21 and PCNA. The upregulation of p21 was controlled by p53 expression in HepG2 but not in Hep3B despite upregulation of Bax protein in both cell lines. Interestingly, p21 may be a remarkable switch to G1 arrest in HepG2 cells, but not in Hep3B cells. In addition, Fas- and mitochondria-mediated pathways were found to be involved in MRE-induced apoptosis in Hep3B cells. The GC-MS analysis of MRE revealed two major constituents of pharmaceutical importance: the flavonoid apigenin (17.04%) and the terpenoid squalene (11.32%). The data presented in this paper introduces G. bruguieri as a promising nontoxic herb with therapeutic potential for HCC. To the authors' knowledge, the present study provides the first report on the anticancer activity of MRE on HCC cells.

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“…A recent study indicated that at least 23% of Egyptians use medicinal plants as a remedy or as a functional food (AbouZid & Mohamed, 2011). The pharmacognosy of Moghat has been studied extensively since the 1960s (Amin & Olfat, 1968;Amin, Olfat, Abd El-Sarnad, & Iskander, 1969).…”

Section: Discussionmentioning

confidence: 99%

Cultural Implications of Moghat (Glossostemon bruguieri) and Breastfeeding in Egypt: A Brief Narrative Review

Aboul‐Enein¹

2013

OJCCNH.org

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The mucilage of the roots of clossostemon bruguieri (moghat)

Cited by 10 publications

References 8 publications

Constituents from Moghat, the Roots of Glossostemon bruguieri (Desf.)

Constituents from Moghat, the Roots of Glossostemon bruguieri (Desf.)

Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells

Cultural Implications of Moghat (Glossostemon bruguieri) and Breastfeeding in Egypt: A Brief Narrative Review

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