The Mouth-COVID Connection: Il-6 Levels in Periodontal Disease — Potential Role in COVID-19-Related Respiratory Complications

Antimicrobial and anti-inflammatory effects of BenTooth: A natural product blend of burdock root, persimmon leaf extracts, and quercetin on periodontal disease

“…Among various cytokines, IL-6 and TNF-α are central to bone metabolism and are known to stimulate osteoclast proliferation through the RANK-RANKL-OPG pathway [ 29 ]. Furthermore, TNF-α and IL-6 majorly induce periodontal degradation by upregulating matrix metalloproteinase (MMP) [ 30 , 31 ]. LPS is also known to intensify inflammation by amplifying the expression of iNOS or COX-2.…”