1984
DOI: 10.1001/archderm.120.9.1186
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The morphologic characteristics of dry skin in atopic dermatitis

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Cited by 25 publications
(11 citation statements)
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“…Recently, detailed evaluation of the relationships between AD and the psychological state has also begun in Japan [9,10], and the interrelationship of psychological states such as depression, tension, and anxiety with the low water content of the stratum corneum in AD patients has been demonstrated. Dry skin is a typical disease state of AD [6,8,26], and Werner [27] has reported low water content of the stratum corneum in this condition. The involvement of stress in the onset and aggravation of psoriasis has also been reported [2,19,20], and low water content of the stratum corneum [21] and decreased water-holding capacity of the skin [23] have been demonstrated.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, detailed evaluation of the relationships between AD and the psychological state has also begun in Japan [9,10], and the interrelationship of psychological states such as depression, tension, and anxiety with the low water content of the stratum corneum in AD patients has been demonstrated. Dry skin is a typical disease state of AD [6,8,26], and Werner [27] has reported low water content of the stratum corneum in this condition. The involvement of stress in the onset and aggravation of psoriasis has also been reported [2,19,20], and low water content of the stratum corneum [21] and decreased water-holding capacity of the skin [23] have been demonstrated.…”
Section: Discussionmentioning
confidence: 99%
“…This condition is common, and associated in at least 4% of cases with AD (26). However, the distinction of this phenotype from AD is so blurred that the rate of association might be higher (27). Another argument for looking at this disorder as a genetic model is that the degradation of filaggrin, a structural protein which packages keratin filaments leads to urocanid acid, a molecule which may serve as an immunomodulator in the epidermis, providing a link between a structural protein basis and immune pathomechanisms in situ (28).…”
Section: For Which Genes Involved In Epidermal Barriermentioning
confidence: 99%
“…It is also well accepted that patients with AD have dry skin that is easily irritated to produce dermatitis [6]. For such a high irritability of the skin, a compromised barrier function of the SC that is demonstrable even in their uninvolved' skin [7][8][9][10] has long been regarded as an important causative factor. In the unaffected skin of AD patients, some investigators found higher irritability [11] or an impaired barrier function [12,13].…”
Section: Introductionmentioning
confidence: 99%