The modulatory effects of leukotrienes C4 and D4 on methacholine- and substance P-induced salivary secretion in rats

Curry, Craig C.; Barbieri, E

doi:10.1016/0090-6980(88)90083-4

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Several endocrine factors may also be at work in bulimia to affect amylase production. Hormones which decrease salivary flow from the parotid glands in preclinical studies include vasopressin, prostaglandin E l and E2, and leukotrienes (Liang & Cascieri, 1979;Yu, 1986;Curry & Barbieri, 1988). Vasoactive intestinal peptide causes an increase in flow (Bobyock & Chernick, 1989).…”

Section: Endocrine Factorsmentioning

confidence: 99%

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Levine

Walton

Franko

et al. 1992

Int. J. Eat. Disord.

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Elevations of serum amylase have been reported in 25–60% of bulimics. This increase in amylase appears to derive from the nonpancreatic fraction of serum amylase and thus underscores its likely association with previous clinical descriptions of parotid gland enlargement among bulimics. The value of measurement of serum amylase as an index of clinical symptomatology in bulimia is currently limited because of substantial overlap of amylase levels in patients and normals, and because of variability in correlations between amylase levels and symptom severity. This article reviews the physiology of amylase secretion from the salivary glands and, in light of previous studies of physiologic alterations in bulimia, assesses factors that may contribute to variance in amylase levels in bulimics. Controlling for these variables in future studies may yield more useful clinical information. © 7992 lohn Wiley & Sons, Inc.

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Section: Endocrine Factorsmentioning

confidence: 99%

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Levine

Walton

Franko

et al. 1992

Int. J. Eat. Disord.

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Arachidonic acid, prostaglandin E₂ and leukotriene C₄ levels in gingiva and submandibular salivary glands of rats fed diets containing n−3 fatty acids

Alam¹,

Bergens²,

Alam³

1991

Lipids

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The effect of dietary n-3 fatty acids on prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) levels in rat salivary glands and gingiva was examined in two separate nutritional studies. In the first set of experiments, two groups of male weanling Sprague-Dawley rats were fed semipurified diets containing 10% corn oil (control group) or 10% menhaden oil (experimental group). Rats were killed after 8 wk on the diets; the fatty acid composition of total phospholipids and the concentrations of PGE2 and its precursor, arachidonic acid, were measured in gingiva and submandibular salivary glands (SMSG). Dietary n-3 fatty acids were incorporated into the tissue phospholipids. Arachidonic acid levels were reduced by 56% in gingiva and SMSG of rats fed menhaden oil compared with the control rats fed the diet containing corn oil. The concentrations of PGE2 in SMSG and gingiva of rats fed the diet containing menhaden oil were reduced by 74% and 83%, respectively. In a subsequent nutritional study, we tested whether the diet-induced reduction in tissue arachidonic acid levels would also result in a corresponding decrease in LTC4 production. Three groups of rats were fed diets containing 5% corn oil (group 1), 4% ethyl ester concentrate of n-3 fatty acids plus 1% corn oil (group 2), or 5% ethyl ester concentrate of n-3 fatty acids (group 3). After 6 wk of feeding, gingiva and SMSG were analyzed for arachidonic acid content and in vitro production of LTC4.(ABSTRACT TRUNCATED AT 250 WORDS)

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Prostaglandin E2 production in submandibular salivary glands of rats in essential fatty acid deficiency

Abdel-Hakim¹,

Alam²,

Alam³

1994

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

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The modulatory effects of leukotrienes C4 and D4 on methacholine- and substance P-induced salivary secretion in rats

Cited by 4 publications

References 17 publications

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Arachidonic acid, prostaglandin E₂ and leukotriene C₄ levels in gingiva and submandibular salivary glands of rats fed diets containing n−3 fatty acids

Prostaglandin E2 production in submandibular salivary glands of rats in essential fatty acid deficiency

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The modulatory effects of leukotrienes C4 and D4 on methacholine- and substance P-induced salivary secretion in rats

Cited by 4 publications

References 17 publications

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Serum amylase in bulimia nervosa: Clinical status and pathophysiology

Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n−3 fatty acids

Prostaglandin E2 production in submandibular salivary glands of rats in essential fatty acid deficiency

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Product

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About

Arachidonic acid, prostaglandin E₂ and leukotriene C₄ levels in gingiva and submandibular salivary glands of rats fed diets containing n−3 fatty acids