The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer

Osuga, Yutaka; Matono, Keiko; Sasatomi, Teruo; Ishibashi, Nobuya; Ohkita, Akira; Mizobe, Tomoaki; Ogo, Shujiro; Ikeda, Satoru; Ozasa, Hiroyuki; Shirouzu, Kazuo

doi:10.1007/s00280-005-0081-9

Cited by 18 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in CRC high expression of MMP-2 and MMP-9 may be important in tumor initiation (34,35), development (36), progression, and metastasis (37). Thus, high expression of MMP-2 and MMP-9 may be used to characterize the behaviors of colorectal carcinoma (38,39). Moreover, high colorectal MMP-9 expression has been implicated in lung metastases (40) and tumor cell resistance to proapoptotic and p53 effects, as well as poor efficacy in postoperative adjuvant chemotherapy (41).…”

Section: R E S E a R C H A R T I C L E M O L M Ementioning

confidence: 99%

Macrophage Migration Inhibitory Factor Promotes Colorectal Cancer

Chen

Yang

et al. 2009

Mol Med

View full text Add to dashboard Cite

A growing body of evidence implicates macrophage migration inhibitory factor (MIF) in tumorigenesis and metastasis. In this study, we investigated whether MIF expression was associated with clinicopathologic features of colorectal carcinoma (CRC), especially in tumors with hepatic metastasis, and whether neutralization of endogenous MIF using anti-MIF therapeutics would inhibit tumor growth and/or decrease the frequency of colorectal hepatic metastases in a mouse colon carcinoma model. The concentration of serum MIF was positively correlated with an increased risk of hepatic metastasis in human patients with CRC (R = 1.25, 95% confidence internal = 1.02-1.52, P = 0.03). MIF was also dramatically upregulated in human colorectal tissue, with 20-40 times as many MIF-positive cells found in the mucosa of patients with CRC than in normal tissue (P < 0.001 ANOVA). Moreover, in those patients with metastatic colorectal cancer in the liver, MIF-positive cells were similarly increased in the diseased hepatic tissue. This increased MIF expression was restricted to diseased tissue and not found in areas of the liver with normal morphology. In subsequent in vitro experiments, we found that addition of recombinant MIF to colonic cell lines significantly increased their invasive properties and the expression of several genes (for example, matrix metalloproteinase 9 and vascular endothelial growth factor) known to be upregulated in cancerous tissue. Finally, we treated mice that had been given CT26 colon carcinoma cell transplants with anti-MIF therapeutics-either the MIF-specific inhibitor ISO-1 or neutralizing anti-MIF antibodies-and observed a significant reduction in tumor burden relative to vehicle-treated animals. Taken together, these data demonstrate that MIF expression was not only correlated with the presence of colorectal cancer but also may play a direct role in cancer development.

show abstract

Section: R E S E a R C H A R T I C L E M O L M Ementioning

confidence: 99%

Macrophage Migration Inhibitory Factor Promotes Colorectal Cancer

Chen

Yang

et al. 2009

Mol Med

View full text Add to dashboard Cite

show abstract

“…MMPs (except membrane-type MMPs) are secreted in proenzyme forms and require proteolytic cleavage at the N terminus for activation. The activation cascade for MMPs in the healthy host is closely tied to the fibrinolytic pathway, and activated MMP-3 is believed to be the major physiological activator of most MMPs, including MMP-9 (27,33). While regulation of MMP production in normal cells is tightly controlled and occurs at many levels, the dysregulation of MMPs often associated with disease (27) could be an important consequence of coinfection.…”

Section: Discussionmentioning

confidence: 99%

“…Occludin, a tight junction protein that contains a putative MMP cleavage site (8), serves as substrate for both MMP-3 and MMP-9 (18,21). Furthermore, MMP-3 can also degrade tight junction claudins and most extracellular matrix proteins (21,33). Aside from proteolytic effects on endothelial cell tight junctions, MMPs also modulate inflammation by either activating or inactivating cytokines and other inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anaplasma phagocytophilum - Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells

Grab

Nyarko

Barat

et al. 2007

Clin Vaccine Immunol

View full text Add to dashboard Cite

“…The expression levels of MMP-2 and MMP-9 were found to be closely linked to venous and lymph node invasion. Ogata et al (24) reported that MMP-9 expression is related to lymph node metastasis and severe venous invasion. Takeuchi et al (22) reported that RECK expression is significantly associated with lymph node metastasis, Dukes' stage and venous invasion.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer

Oshima¹,

Kunisaki²,

Yoshihara³

et al. 2008

Oncol Rep

View full text Add to dashboard Cite

Abstract. Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and membrane-type matrix metalloproteinase 1 (MT1-MMP) are involved in colorectal cancer invasion and metastasis. Reversion-inducing cysteinerich protein with Kazal motifs (RECK) inhibits MMP-2, MMP-9 and MT1-MMP. We examined the clinicopathological significance of the relative expression of these genes in patients with colorectal cancer, especially with regard to metastasis. We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 205 patients with untreated colorectal carcinoma. MMP-2, MMP-9, MT1-MMP, RECK and ß-actin mRNA of cancer tissue and adjacent normal mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction. MT1-MMP gene expression was higher in cancer tissue than in adjacent normal mucosa. In contrast, MMP-2, MMP-9 and RECK gene expression levels were lower in cancer tissue than in adjacent normal mucosa. As for the relationship between the gene expression and clinicopathological factors, MMP-2 expression correlated with the depth of invasion, venous invasion and liver metastasis; MMP-9 and RECK expression correlated with venous invasion. There were positive correlations among the gene expression levels of MMP-2, MMP-9 and RECK. MMP-2 gene expression was considered a useful predictor of liver metastasis from colorectal cancer.

show abstract

The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer

Abstract: The efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines such as UFT and 5'-DFUR may not be as great for patients with a tumor positive for MMP-9 having a greater risk to postoperative recurrence.

Cited by 18 publications

References 31 publications

Macrophage Migration Inhibitory Factor Promotes Colorectal Cancer

Macrophage Migration Inhibitory Factor Promotes Colorectal Cancer

Anaplasma phagocytophilum - Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells

Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer

Contact Info

Product

Resources

About