2012
DOI: 10.18632/aging.100493
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Abstract: Although antioxidants have been repeatedly tested in animal models and clinical studies, there is no evidence that antioxidants reduce already developed age-related decline. Recently we demonstrated that mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) delayed some manifestations of aging. Here we compared effects of SkQ1 and N-acetyl-L-cysteine (NAC) on age-dependent decline in blood levels of leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1), testo… Show more

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Cited by 45 publications
(28 citation statements)
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References 47 publications
(58 reference statements)
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“…Recently, Skulachev et al reported that mitochondrial ROS are especially important for progression of an aging phenotype, which was shown using the mitochondrial targeted antioxidant SkQ1 (24,44). In support of this notion, Mito-TEMPO efficiently suppressed CSE-induced HBEC senescence, suggesting that ROS in CSE is mainly involved in the initial step of mitochondrial fragmentation and that subsequent ROS release from fragmented mitochondria is the more crucial mechanism for CSEinduced HBEC senescence.…”
Section: L743mentioning
confidence: 85%
See 1 more Smart Citation
“…Recently, Skulachev et al reported that mitochondrial ROS are especially important for progression of an aging phenotype, which was shown using the mitochondrial targeted antioxidant SkQ1 (24,44). In support of this notion, Mito-TEMPO efficiently suppressed CSE-induced HBEC senescence, suggesting that ROS in CSE is mainly involved in the initial step of mitochondrial fragmentation and that subsequent ROS release from fragmented mitochondria is the more crucial mechanism for CSEinduced HBEC senescence.…”
Section: L743mentioning
confidence: 85%
“…Although CSE contains a wide array of toxic components, including ROS, the precise source of ROS involved in progression of cellular senescence in response to CSE exposure remains to be clearly elucidated. Mitochondria are a major source of intrinsic ROS production, and mitochondrial ROS is considered to be associated with aging (24,44,52). Accordingly, we hypothesized that mitochondrial ROS production participates in the regulation of CSE-induced cellular senescence.…”
Section: Mitochondrial Ros Production Is Involved In Cse-induced Hbecmentioning
confidence: 99%
“…Since there is evidence of mitochondrial oxidative stress in age-related diseases an intracellular antioxidant may be more useful. For example, the mitochondrial antioxidant SkQ1 reverses ageing-related biomarkers in rats, whereas N-acetyl cysteine is ineffective [143]. Nrf2 activators are of particular interest as Nrf2 may be defective in several diseases of accelerated ageing, including COPD, chronic kidney disease, neurodegeneration, cardiovascular disease and cancer [52,144].…”
Section: Pharmacological Therapiesmentioning
confidence: 99%
“…SkQ1 and its analogs are efficient in the prevention of some age-associated pathologies, and they have therapeutic effects in animal models of diseases associated with inflammatory response (heart, brain, and kidney ischemic injury [27, 28], pyelonephritis [29], eye diseases [30, 31], sarcopenia [32], and dermal wound healing [33]). SkQ1 delays the development of various markers of aging and prolongs the lifespan of various animals [20, 22, 34, 35]. The antiinflammatory and vasoprotective action of SkQ1 could underlie some of these effects.…”
Section: Introductionmentioning
confidence: 99%