1956
DOI: 10.1172/jci103308
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Abstract: In 1948, Mason and Sprague (1) reported the isolation of hydrocortisone from the urine of a patient with Cushing's syndrome, and thus provided evidence that hydrocortisone was produced by the human adrenal cortex. Subsequently, hydrocortisone was found to be one of the principal corticoids in human adrenal gland perfusates (2) and in human peripheral blood (3). These observations strongly suggest that hydrocortisone may be the principal corticosteroid secreted by the adrenal cortex of man. Recent studies (4, 5… Show more

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Cited by 173 publications
(121 citation statements)
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“…Previous studies have examined the effects of altered thyroid function on the secretion and metabolism of adrenocortical hormones. In thyrotoxic states the degradation of cortisol is accelerated, but its rate of production is also increased (5,10,12,13). These observations indicate that a degree of adrenal cortical hypersensitivity would be sustained in hyperthyroidism as a response to increased need.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Previous studies have examined the effects of altered thyroid function on the secretion and metabolism of adrenocortical hormones. In thyrotoxic states the degradation of cortisol is accelerated, but its rate of production is also increased (5,10,12,13). These observations indicate that a degree of adrenal cortical hypersensitivity would be sustained in hyperthyroidism as a response to increased need.…”
Section: Discussionmentioning
confidence: 92%
“…Thus, in thyrotoxic states the degradation of cortisol is accelerated, but its rate of production is also increased, so that circulating levels of cortisol remain normal (5,10,12,13). These observations indicate that a degree of adrenocortical hyperactivity would be sustained in hyperthyroidism as a response to increased need.…”
Section: Introductionmentioning
confidence: 94%
“…The isotopic dilution technique for determination of the pool and turnover of a substance is based upon a number of assumptions and is subject to limitations which have been discussed in detail previously (29). In the present study the major limitations are two: 1) the relatively large fraction of the injected tracer which is rapidly excreted in urine, and 2) the small quantity of oxalate present in 2-or 4-hour urine specimens.…”
Section: Physiological Disposition Of Oxalate In Manmentioning
confidence: 90%
“…Thus, in thyrotoxic states the degradation of cortisol is accelerated but its rate of production is also increased, so that circulating levels of cortisol remain normal (1)(2)(3)(4). These observations indicate that a degree of adrenocortical hyperactivity would be sustained in hyperthyroidism as a response to increased need.…”
Section: Introductionmentioning
confidence: 99%