The migration of bisphenols from beverage cans and reusable sports bottles

Kovačić, Ana; Gys, Celine; Gulin, Martin Rafael; Kosjek, Tina; Heath, David; Heath, Ester

doi:10.1016/j.foodchem.2020.127326

Cited by 26 publications

(9 citation statements)

References 41 publications

(26 reference statements)

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“…Las principales rutas de exposición a disruptores endocrinos son la ingesta, inhalación y absorción dérmica (Darbre, 2019). Los cambios de pH y temperatura favorecen la liberación de disruptores del producto que lo contiene, como se ha observado en latas con recubrimiento interno de resina epóxica, en donde los cambios fisicoquímicos inducen una liberación de monómeros de BPA hacia el producto enlatado, lo que aumenta la posibilidad de ingerir el disruptor al consumir el alimento (Kovačič et al, 2020).…”

Section: Disruptores Endócrinosunclassified

Los Disruptores Endocrinos Como Obesógenos Ambientales: Efectos en Proteínas Adipogénicas Clave

Guerrero-Meza

Vega-Morales

Rubio

et al. 2022

ESJ

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Los disruptores endocrinos (EDC) son compuestos químicos exógenos de origen sintético o natural que interfieren en las funciones hormonales. Se estima que más de 1000 compuestos químicos presentes en el medio ambiente poseen una posible actividad disruptora. La exposición a EDC se ha relacionado con el desarrollo de múltiples enfermedades como la obesidad. Los obesógenos son compuestos químicos xenobióticos que regulan y promueven inadecuadamente la acumulación de lípidos y la adipogénesis. La adipogénesis es el proceso mediante el cual las células progenitoras similares a fibroblastos restringen su destino a las células adipogénicas, acumulan nutrientes y se convierten en adipocitos maduros. Para conocer las principales evidencias científicas de la última década sobre los efectos obesogénicos de los EDC, se realizó una búsqueda en la literatura empleando las plataformas Scopus y Pubmed. El análisis arrojó 60 artículos originales de los cuales 24 fueron seleccionados por brindar información sobre proteínas adipogénicas clave. Los datos muestran que los EDC como los compuestos de organoestaño, ftalatos y bisfenoles estimulan vías de señalización adipogénicas clave mediadas por el receptor activado por el proliferador de peroxisomas-γ y la CCAAT/proteína de unión al potenciador-α, factores similares a krüppel y receptores de hormonas tiroideas, estrógeno y glucocorticoides; en relación a factores como el tipo, la concentración y el período de exposición al disruptor. Además, sus efectos podrían ser potenciados por la presencia de una dieta alta en grasas o una mezcla de diferentes tipos de EDC. En conclusión, los EDC inducen efectos obesogénicos a través de la estimulación de vías de señalización adipogénicas; y se requieren más estudios para comprender los mecanismos moleculares que subyacen a los efectos de los EDC para determinar su relevancia fisiológica y promover aún más su regulación en la industria. Endocrine disruptors (EDC) are exogenous chemical compounds of synthetic or natural origin which interfere with hormonal functions. It is estimated that more than 1000 chemical compounds present in the enviroment have possible disruptive activity. Exposure to endocrine disruptors has been linked to the development of multiple diseases such as obesity. Obesogens are xenobiotic chemical compounds that inappropriately regulate and promote lipid accumulation and adipogenesis. Adipogenesis is the process by which fibroblast-like progenitor cells restrict their fate to adipogenic cells, accumulate nutrients, and develop into mature adipocytes. To know the main scientific evidence from the last decade regarding the obesogenic effects of EDC, a literature research was conducted using Scopus and Pubmed platforms. The analysis showed 60 original articles from which 24 were selected for providing information on key adipogenic proteins. Data shows that EDC such as organotin compounds, phthalates and bisphenols stimulate key adipogenic signaling pathways mediated by peroxisome proliferator activated receptor-γ and CCAAT-enhancer binding protein-α, krüppel like factors, and thyroid, estrogen and glucocorticoid receptors; in relation to factors like type, concentration and period of exposure to the disruptor. Furthermore, their effects could be potentiated by the presence of a high fat diet or a mix of diferent types of EDC. In conclusion, EDC induce obesogenic effects through the stimulation of adipogenic signaling pathways; in addition, more studies are required to understand the molecular mechanisms that underlie EDC effects to determine their physiological relevance, and to further promote their regulation in the industry.

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Section: Disruptores Endócrinosunclassified

Los Disruptores Endocrinos Como Obesógenos Ambientales: Efectos en Proteínas Adipogénicas Clave

Guerrero-Meza

Vega-Morales

Rubio

et al. 2022

ESJ

View full text Add to dashboard Cite

show abstract

“…Among others, BPA and BPS are used in the manufacture of polymeric coatings (i.e., the resin lining of cans) and thermoplastic, a versatile material with a huge range of applications. As individuals we come into contact with products made from thermoplastic, for instance, in food packaging, plastic tableware, drinking bottles, dental composites, contact lenses, and children with toys and baby pacifiers [26][27][28][29][30][31]. Thereby, poly(bisphenol A carbonate) [BPA-PC; CAS Registry No.…”

Section: Beyond Toxicity Tests: the Blind Spots In Risk Assessmentmentioning

confidence: 99%

Recording from an Identified Neuron Efficiently Reveals Hazard for Brain Function in Risk Assessment

Machnik

Schuster

2021

Molecules

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Modern societies use a continuously growing number of chemicals. Because these are released into the environment and are taken up by humans, rigorous (but practicable) risk assessment must precede the approval of new substances for commerce. A number of tests is applicable, but it has been very difficult to efficiently assay the effect of chemicals on communication and information processing in vivo in the adult vertebrate brain. Here, we suggest a straightforward way to rapidly and accurately detect effects of chemical exposure on action potential generation, synaptic transmission, central information processing, and even processing in sensory systems in vivo by recording from a single neuron. The approach is possible in an identified neuron in the hindbrain of fish that integrates various sources of information and whose properties are ideal for rapid analysis of the various effects chemicals can have on the nervous system. The analysis uses fish but, as we discuss here, key neuronal functions are conserved and differences can only be due to differences in metabolism or passage into the brain, factors that can easily be determined. Speed and efficiency of the method, therefore, make it suitable to provide information in risk assessment, as we illustrate here with the effects of bisphenols on adult brain function.

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“…Traditional techniques for BPs enrichment were focused on liquid–liquid extraction (LLE) 35 and solid-phase extraction (SPE). 36 Although these pre-treatment methods had large volume capacities, they usually needed a high consumption of organic solvent for conditioning and elution. In addition to the well-established microextraction techniques, mainly solid phase microextraction (SPME), 37 dispersive liquid–liquid microextraction (DLLME), 38 stir bar sorptive extraction (SBSE), 39 supramolecular solvent microextraction (SSME), hallow-fiber liquid phase microextraction (HFLPME), QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe), focused ultrasonic solid–liquid extraction (FUSLE), 40,41 Ultrasound-assisted extraction-dispersive solid phase extraction (UAE-DSPE), 30 microwave-assisted extraction (MAE), mixed-mode anion-exchange (MAX), mixed-mode cation-exchange (MCX), and headspace solid-phase microextraction (HS-SPME) have been successfully applied for the isolation of BPs from various matrices.…”

Section: Introductionmentioning

confidence: 99%

Gas chromatography–mass spectrometric determination of bisphenol residues by dispersive solid phase extraction followed by activated carbon spheres cleanup from fish feed samples

Talari

Ganji

Tiruveedula³

2023

Eur J Mass Spectrom (Chichester)

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Bisphenols are known endocrine disruptors commonly utilized in food packaging and storage materials, which frequently come into touch with multiple food products packed in them. The bisphenols in fish feed and other feed materials for aquatic organisms are harmful. The consumption of such marine foods is hazardous. Hence, the feed of aquatic products needs to be verified for the presence of bisphenols. The present study was focused on developing and validating a rapid, selective, and sensitive method to quantify 11 bisphenols from the fish feed with dispersive solid-phase extraction, which was cleaned by an optimized amount of activated carbon spheres and silylated by N,O-bis(trimethylsilyl)trifluoro acetamide and analyzed by gas chromatography–mass spectrometry. The new method was rigorously tested and verified after carefully tuning various parameters affecting analyte recovery. Limit of detection (LOD) were set at 0.5–5 ng/g and limit of quantification (LOQ) at 1–10 ng/g, respectively, resulting in 95–114% recoveries. Interday and intraday precisions in terms of relative standard deviation were found to be less than 11%. The proposed approach was effectively applied in floating and sinking fish feeds. The obtained results showed that higher concentration of bisphenol A, followed by bisphenol TMC, and bisphenol M at a concentration of 256.10, 159.01, and 168.82 ng/g in floating feed and 88.04, 200.79, and 98.03 ng/g in sinking feed samples, respectively.

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The migration of bisphenols from beverage cans and reusable sports bottles

Cited by 26 publications

References 41 publications

Los Disruptores Endocrinos Como Obesógenos Ambientales: Efectos en Proteínas Adipogénicas Clave

Los Disruptores Endocrinos Como Obesógenos Ambientales: Efectos en Proteínas Adipogénicas Clave

Recording from an Identified Neuron Efficiently Reveals Hazard for Brain Function in Risk Assessment

Gas chromatography–mass spectrometric determination of bisphenol residues by dispersive solid phase extraction followed by activated carbon spheres cleanup from fish feed samples

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