The Metabolism and Immune Environment in Diffuse Large B-Cell Lymphoma

Wu, Jianbo; Meng, Fuqing; Ran, Danyang; Song, Yalong; Dang, Yunkun; Lai, Fan; Yang, Longyan; Deng, Mi; Song, Yuqin; Zhu, Jun

doi:10.3390/metabo13060734

Cited by 3 publications

(2 citation statements)

References 140 publications

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“…Thus, a study design that minimizes biases is necessary to elucidate this potential causality. Moreover, given the intricate relationship between immune cells and metabolites [14][15][16] , and ndings that certain metabolites, such as circulating metabolites 17 , can serve as biomarkers for epilepsy, it is conceivable that metabolites may act as potential mediators between immune cells and epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Mendelian Randomization Analysis of the Causal Relationship Between Immune Cells and Epilepsy: The Mediating Role of Metabolites

Chen,

Yu,

Liu

et al. 2024

Preprint

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Our study investigated the causal relationship between immune cells, metabolites, and epilepsy using two-sample Mendelian Randomization (MR) and mediation MR analysis of 731 immune cell traits and 1,400 metabolites. Our core methodology centered on inverse-variance weighted MR, supplemented by other methods. This approach was crucial in clarifying the potential intermediary functions of metabolites in the genetic links between traits of immune cells and epilepsy. We found a causal relationship between immune cells and epilepsy. Specifically, the genetically predicted levels of CD64 on CD14-CD16 are positively correlated with the risk of epilepsy (p < 0.001, OR = 1.0826, 95% CI 1.0361–1.1312). Similarly, metabolites also exhibit a causal relationship with both immune cells (OR = 1.0438, 95% CI:1.0087–1.0801, p = 0.0140) and epilepsy (p = 0.0334, OR = 1.0897, 95% CI: 1.0068–1.1795), and sensitivity analysis was conducted to further validate these relationships. Importantly, our intermediate MR results suggest that the metabolite Paraxanthine to linoleate (18:2n6) ratio may mediate the causal relationship between immune cell CD64 on CD14-CD16 and epilepsy, with a mediation effect of 5.05%. The results suggest the importance of specific immune cell levels and metabolites in understanding epilepsy's pathogenesis. This is significant for understanding the pathogenesis of epilepsy and its prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

Mendelian Randomization Analysis of the Causal Relationship Between Immune Cells and Epilepsy: The Mediating Role of Metabolites

Chen,

Yu,

Liu

et al. 2024

Preprint

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“… Reduction in patients survival. Decline [ 28 ] Silencing OGT results in decreased activity of NF-kB and NFATc. Growth inhibition.…”

Section: Introductionmentioning

confidence: 99%

Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?

Zhuang,

Liu,

et al. 2024

Pharmaceuticals

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The circulatory system is a closed conduit system throughout the body and consists of two parts as follows: the cardiovascular system and the lymphatic system. Hematological malignancies usually grow and multiply in the circulatory system, directly or indirectly affecting its function. These malignancies include multiple myeloma, leukemia, and lymphoma. O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) regulates the function and stability of substrate proteins through O-GlcNAc modification. Abnormally expressed OGT is strongly associated with tumorigenesis, including hematological malignancies, colorectal cancer, liver cancer, breast cancer, and prostate cancer. In cells, OGT can assemble with a variety of proteins to form complexes to exercise related biological functions, such as OGT/HCF-1, OGT/TET, NSL, and then regulate glucose metabolism, gene transcription, cell proliferation, and other biological processes, thus affecting the development of hematological malignancies. This review summarizes the complexes involved in the assembly of OGT in cells and the role of related OGT complexes in hematological malignancies. Unraveling the complex network regulated by the OGT complex will facilitate a better understanding of hematologic malignancy development and progression.

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Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization

Chen,

Yu,

Liu

et al. 2024

Sci Rep

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The Metabolism and Immune Environment in Diffuse Large B-Cell Lymphoma

Cited by 3 publications

References 140 publications

Mendelian Randomization Analysis of the Causal Relationship Between Immune Cells and Epilepsy: The Mediating Role of Metabolites

Mendelian Randomization Analysis of the Causal Relationship Between Immune Cells and Epilepsy: The Mediating Role of Metabolites

Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?

Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization

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